Estimated cognitive decline in patients with schizophrenia

A multicenter study

for COCORO

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aim: Studies have reported that cognitive decline occurs after the onset of schizophrenia despite heterogeneity in cognitive function among patients. The aim of this study was to investigate the degree of estimated cognitive decline in patients with schizophrenia by comparing estimated premorbid intellectual functioning and current intellectual functioning. Methods: A total of 446 patients with schizophrenia (228 male, 218 female), consisting of three sample sets obtained from 11 psychiatric facilities, and 686 healthy controls participated in this study. The Wechsler Adult Intelligence Scale-III (WAIS-III) was used to measure the participants’ current full-scale IQ (FSIQ). The premorbid IQ was estimated using the Japanese Adult Reading Test-25. Estimated cognitive decline (difference score) was defined as the difference between the estimated premorbid IQ and the current FSIQ. Results: Patients with schizophrenia showed greater estimated cognitive decline, a lower FSIQ, and a lower premorbid IQ compared with the healthy controls. The mean difference score, FSIQ, and estimated premorbid IQ were −16.3, 84.2, and 100.5, respectively, in patients with schizophrenia. Furthermore, 39.7% of the patients had a difference score of 20 points or greater decline. A discriminant analysis showed that the difference score accurately predicted 81.6% of the patients and healthy controls. Conclusion: These results show the distribution of difference score in patients with schizophrenia. These findings may contribute to assessing the severity of estimated cognitive decline and identifying patients with schizophrenia who suffer from cognitive decline.

Original languageEnglish
Pages (from-to)294-300
Number of pages7
JournalPsychiatry and Clinical Neurosciences
Volume71
Issue number5
DOIs
Publication statusPublished - May 1 2017

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Multicenter Studies
Schizophrenia
Cognitive Dysfunction
Discriminant Analysis
Intelligence
Cognition
Psychiatry
Reading

Keywords

  • cognition
  • cognitive decline
  • intelligence
  • multicenter study
  • schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Estimated cognitive decline in patients with schizophrenia : A multicenter study. / for COCORO.

In: Psychiatry and Clinical Neurosciences, Vol. 71, No. 5, 01.05.2017, p. 294-300.

Research output: Contribution to journalArticle

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abstract = "Aim: Studies have reported that cognitive decline occurs after the onset of schizophrenia despite heterogeneity in cognitive function among patients. The aim of this study was to investigate the degree of estimated cognitive decline in patients with schizophrenia by comparing estimated premorbid intellectual functioning and current intellectual functioning. Methods: A total of 446 patients with schizophrenia (228 male, 218 female), consisting of three sample sets obtained from 11 psychiatric facilities, and 686 healthy controls participated in this study. The Wechsler Adult Intelligence Scale-III (WAIS-III) was used to measure the participants’ current full-scale IQ (FSIQ). The premorbid IQ was estimated using the Japanese Adult Reading Test-25. Estimated cognitive decline (difference score) was defined as the difference between the estimated premorbid IQ and the current FSIQ. Results: Patients with schizophrenia showed greater estimated cognitive decline, a lower FSIQ, and a lower premorbid IQ compared with the healthy controls. The mean difference score, FSIQ, and estimated premorbid IQ were −16.3, 84.2, and 100.5, respectively, in patients with schizophrenia. Furthermore, 39.7{\%} of the patients had a difference score of 20 points or greater decline. A discriminant analysis showed that the difference score accurately predicted 81.6{\%} of the patients and healthy controls. Conclusion: These results show the distribution of difference score in patients with schizophrenia. These findings may contribute to assessing the severity of estimated cognitive decline and identifying patients with schizophrenia who suffer from cognitive decline.",
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author = "{for COCORO} and Haruo Fujino and Chika Sumiyoshi and Yuka Yasuda and Hidenaga Yamamori and Michiko Fujimoto and Masaki Fukunaga and Kenichiro Miura and Yuto Takebayashi and Naohiro Okada and Shuichi Isomura and Naoko Kawano and Atsuhito Toyomaki and Hironori Kuga and Masanori Isobe and Kazuto Oya and Yuko Okahisa and Manabu Takaki and Naoki Hashimoto and Masaki Kato and Toshiaki Onitsuka and Takefumi Ueno and Tohru Ohnuma and Kiyoto Kasai and Norio Ozaki and Tomiki Sumiyoshi and Osamu Imura and Ryota Hashimoto",
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AU - Fujino, Haruo

AU - Sumiyoshi, Chika

AU - Yasuda, Yuka

AU - Yamamori, Hidenaga

AU - Fujimoto, Michiko

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AU - Miura, Kenichiro

AU - Takebayashi, Yuto

AU - Okada, Naohiro

AU - Isomura, Shuichi

AU - Kawano, Naoko

AU - Toyomaki, Atsuhito

AU - Kuga, Hironori

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AU - Oya, Kazuto

AU - Okahisa, Yuko

AU - Takaki, Manabu

AU - Hashimoto, Naoki

AU - Kato, Masaki

AU - Onitsuka, Toshiaki

AU - Ueno, Takefumi

AU - Ohnuma, Tohru

AU - Kasai, Kiyoto

AU - Ozaki, Norio

AU - Sumiyoshi, Tomiki

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N2 - Aim: Studies have reported that cognitive decline occurs after the onset of schizophrenia despite heterogeneity in cognitive function among patients. The aim of this study was to investigate the degree of estimated cognitive decline in patients with schizophrenia by comparing estimated premorbid intellectual functioning and current intellectual functioning. Methods: A total of 446 patients with schizophrenia (228 male, 218 female), consisting of three sample sets obtained from 11 psychiatric facilities, and 686 healthy controls participated in this study. The Wechsler Adult Intelligence Scale-III (WAIS-III) was used to measure the participants’ current full-scale IQ (FSIQ). The premorbid IQ was estimated using the Japanese Adult Reading Test-25. Estimated cognitive decline (difference score) was defined as the difference between the estimated premorbid IQ and the current FSIQ. Results: Patients with schizophrenia showed greater estimated cognitive decline, a lower FSIQ, and a lower premorbid IQ compared with the healthy controls. The mean difference score, FSIQ, and estimated premorbid IQ were −16.3, 84.2, and 100.5, respectively, in patients with schizophrenia. Furthermore, 39.7% of the patients had a difference score of 20 points or greater decline. A discriminant analysis showed that the difference score accurately predicted 81.6% of the patients and healthy controls. Conclusion: These results show the distribution of difference score in patients with schizophrenia. These findings may contribute to assessing the severity of estimated cognitive decline and identifying patients with schizophrenia who suffer from cognitive decline.

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