Establishment and characterization of a mantle cell lymphoma cell line

H. O.Jong Jeon, Chul Woo Kim, Tadashi Yoshino, Tadaatsu Akagi

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

A mantle cell lymphoma (MCL) cell line (JeKo-1) was established from peripheral blood mononuclear cells of a patient with a large cell variant of MCL showing leukaemic conversion. JeKo-1 cells were Epstein-Barr virus negative and showed a B-cell phenotype with IgM+, IgD+, CD3-, CD5+, CD10-, CD19+, CD20+ and CD23-; they overexpressed cyclin D1, Bcl-2, c- Myc and Rb proteins. Bcl-1/J(H) gene rearrangement was confirmed by polymerase chain reaction, although karyotypic analysis showed 40/41 chromosomes devoid of apparent t(11;14)(q13;q32) translocation. JeKo-1 cells were highly tumourigenic in SCID mice.

Original languageEnglish
Pages (from-to)1323-1326
Number of pages4
JournalBritish Journal of Haematology
Volume102
Issue number5
DOIs
Publication statusPublished - Oct 5 1998

Keywords

  • CD5
  • Cell line
  • Large cell variant
  • Mantle cell lymphoma
  • PRAD1/cyclin D1

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Establishment and characterization of a mantle cell lymphoma cell line'. Together they form a unique fingerprint.

  • Cite this