ERV3 Human endogenous provirus mRNAs are expressed in normal and malignant tissues and cells, but not in choriocarcinoma tumor cells

Maurice Cohen, Nobuyuki Kato, Erik Larsson

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Messenger RNA expression of a human endogenous provirus, ERV3, has been characterized in 170 specimens of normal and malignant human tissues and cells. In contrast to the high expression in first‐trimester and full‐term placental chorionic villi, most other human tissues expressed ERV3 mRNAs at a level of 2–30% of placenta. However, ERV3 mRNAs were not detected in choriocarcinoma tumor cell lines. These studies suggest that the ERV3 provirus may have been preempted for a biological function and disruption of its mRNA expression results in choriocarcinoma.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalJournal of Cellular Biochemistry
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 1988
Externally publishedYes

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Keywords

  • choriocarcinoma
  • human endogenous provirus
  • proviral mRNA expression

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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