TY - JOUR
T1 - ERV3 Human endogenous provirus mRNAs are expressed in normal and malignant tissues and cells, but not in choriocarcinoma tumor cells
AU - Cohen, Maurice
AU - Kato, Nobuyuki
AU - Larsson, Erik
PY - 1988/2
Y1 - 1988/2
N2 - Messenger RNA expression of a human endogenous provirus, ERV3, has been characterized in 170 specimens of normal and malignant human tissues and cells. In contrast to the high expression in first‐trimester and full‐term placental chorionic villi, most other human tissues expressed ERV3 mRNAs at a level of 2–30% of placenta. However, ERV3 mRNAs were not detected in choriocarcinoma tumor cell lines. These studies suggest that the ERV3 provirus may have been preempted for a biological function and disruption of its mRNA expression results in choriocarcinoma.
AB - Messenger RNA expression of a human endogenous provirus, ERV3, has been characterized in 170 specimens of normal and malignant human tissues and cells. In contrast to the high expression in first‐trimester and full‐term placental chorionic villi, most other human tissues expressed ERV3 mRNAs at a level of 2–30% of placenta. However, ERV3 mRNAs were not detected in choriocarcinoma tumor cell lines. These studies suggest that the ERV3 provirus may have been preempted for a biological function and disruption of its mRNA expression results in choriocarcinoma.
KW - choriocarcinoma
KW - human endogenous provirus
KW - proviral mRNA expression
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U2 - 10.1002/jcb.240360203
DO - 10.1002/jcb.240360203
M3 - Article
C2 - 3356751
AN - SCOPUS:0023872105
VL - 36
SP - 121
EP - 128
JO - Journal of supramolecular structure and cellular biochemistry
JF - Journal of supramolecular structure and cellular biochemistry
SN - 0730-2312
IS - 2
ER -