Eradication of HPV post-surgical treatments, itscorrelation with specific types, types of surgery and the physical status

Jin Fen, Mitsuo Yoshinouchi, Keiichiro Nakamura, Junichi Kodama, Yasutomo Nasu, Kenji Yamato, Yuji Hiramatsu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Low-risk human papillomaviruses (HPVs) will be completely eradicated as long as most visible lesions are treated. However, it is uncertain whether this is also the case for high-risk HPVs that are capable of causing cervical cancer. Many recent studies have demonstrated a high incidence of HPV persistence during post-conization or loop electrosurgical excision (LEEP) due to high-grade cervical intraepithelial neoplasia (CIN). In this report, we correlated the post-operative HPV status with pre-operative HPV type, types of surgery and HPVs physical status. Post-operative HPV E6 amplification by nested PCR was carried out for 157 female patients with positive pre-operative HPV. They underwent LEEPs, therapeutic laser conizations, and simple or radical hysterectomies. We found that high-risk types of HPVs were eradicated in 26.4% (42/159) of patients after extirpation of the lesions. The clearance rate of HPVs increased to 39.2% (40/102), excluding patients with other high-risk (OHR) kinds of type 31, 52b and 58, since OHR persisted after almost all surgeries. Eradication of HPV after radical hysterectomies are highly expected for patients with invasive cancer (70.0%, when excluding OHR), while more than half of them with CIN continue to carry pre-operative types of HPV or some different types from before treatment. Type 33 is most frequently persistent among types 16, 18 and 33. Persistent high-risk HPVs increase the risk for recurrence of post-surgical treatments of CFN, but the incidence is not high as long as the lesion is completely removed.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalOncology Reports
Volume12
Issue number2
Publication statusPublished - Aug 2004

Fingerprint

Therapeutics
Conization
Cervical Intraepithelial Neoplasia
Hysterectomy
Incidence
Uterine Cervical Neoplasms
Lasers
Recurrence
Polymerase Chain Reaction
Neoplasms

Keywords

  • Cervical cancer
  • Cervical dysplasia
  • Eradication
  • Human papillomavirus
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Eradication of HPV post-surgical treatments, itscorrelation with specific types, types of surgery and the physical status. / Fen, Jin; Yoshinouchi, Mitsuo; Nakamura, Keiichiro; Kodama, Junichi; Nasu, Yasutomo; Yamato, Kenji; Hiramatsu, Yuji.

In: Oncology Reports, Vol. 12, No. 2, 08.2004, p. 375-379.

Research output: Contribution to journalArticle

Fen, Jin ; Yoshinouchi, Mitsuo ; Nakamura, Keiichiro ; Kodama, Junichi ; Nasu, Yasutomo ; Yamato, Kenji ; Hiramatsu, Yuji. / Eradication of HPV post-surgical treatments, itscorrelation with specific types, types of surgery and the physical status. In: Oncology Reports. 2004 ; Vol. 12, No. 2. pp. 375-379.
@article{60498223748c452995cc6a914e5ee65e,
title = "Eradication of HPV post-surgical treatments, itscorrelation with specific types, types of surgery and the physical status",
abstract = "Low-risk human papillomaviruses (HPVs) will be completely eradicated as long as most visible lesions are treated. However, it is uncertain whether this is also the case for high-risk HPVs that are capable of causing cervical cancer. Many recent studies have demonstrated a high incidence of HPV persistence during post-conization or loop electrosurgical excision (LEEP) due to high-grade cervical intraepithelial neoplasia (CIN). In this report, we correlated the post-operative HPV status with pre-operative HPV type, types of surgery and HPVs physical status. Post-operative HPV E6 amplification by nested PCR was carried out for 157 female patients with positive pre-operative HPV. They underwent LEEPs, therapeutic laser conizations, and simple or radical hysterectomies. We found that high-risk types of HPVs were eradicated in 26.4{\%} (42/159) of patients after extirpation of the lesions. The clearance rate of HPVs increased to 39.2{\%} (40/102), excluding patients with other high-risk (OHR) kinds of type 31, 52b and 58, since OHR persisted after almost all surgeries. Eradication of HPV after radical hysterectomies are highly expected for patients with invasive cancer (70.0{\%}, when excluding OHR), while more than half of them with CIN continue to carry pre-operative types of HPV or some different types from before treatment. Type 33 is most frequently persistent among types 16, 18 and 33. Persistent high-risk HPVs increase the risk for recurrence of post-surgical treatments of CFN, but the incidence is not high as long as the lesion is completely removed.",
keywords = "Cervical cancer, Cervical dysplasia, Eradication, Human papillomavirus, Surgery",
author = "Jin Fen and Mitsuo Yoshinouchi and Keiichiro Nakamura and Junichi Kodama and Yasutomo Nasu and Kenji Yamato and Yuji Hiramatsu",
year = "2004",
month = "8",
language = "English",
volume = "12",
pages = "375--379",
journal = "Oncology Reports",
issn = "1021-335X",
publisher = "Spandidos Publications",
number = "2",

}

TY - JOUR

T1 - Eradication of HPV post-surgical treatments, itscorrelation with specific types, types of surgery and the physical status

AU - Fen, Jin

AU - Yoshinouchi, Mitsuo

AU - Nakamura, Keiichiro

AU - Kodama, Junichi

AU - Nasu, Yasutomo

AU - Yamato, Kenji

AU - Hiramatsu, Yuji

PY - 2004/8

Y1 - 2004/8

N2 - Low-risk human papillomaviruses (HPVs) will be completely eradicated as long as most visible lesions are treated. However, it is uncertain whether this is also the case for high-risk HPVs that are capable of causing cervical cancer. Many recent studies have demonstrated a high incidence of HPV persistence during post-conization or loop electrosurgical excision (LEEP) due to high-grade cervical intraepithelial neoplasia (CIN). In this report, we correlated the post-operative HPV status with pre-operative HPV type, types of surgery and HPVs physical status. Post-operative HPV E6 amplification by nested PCR was carried out for 157 female patients with positive pre-operative HPV. They underwent LEEPs, therapeutic laser conizations, and simple or radical hysterectomies. We found that high-risk types of HPVs were eradicated in 26.4% (42/159) of patients after extirpation of the lesions. The clearance rate of HPVs increased to 39.2% (40/102), excluding patients with other high-risk (OHR) kinds of type 31, 52b and 58, since OHR persisted after almost all surgeries. Eradication of HPV after radical hysterectomies are highly expected for patients with invasive cancer (70.0%, when excluding OHR), while more than half of them with CIN continue to carry pre-operative types of HPV or some different types from before treatment. Type 33 is most frequently persistent among types 16, 18 and 33. Persistent high-risk HPVs increase the risk for recurrence of post-surgical treatments of CFN, but the incidence is not high as long as the lesion is completely removed.

AB - Low-risk human papillomaviruses (HPVs) will be completely eradicated as long as most visible lesions are treated. However, it is uncertain whether this is also the case for high-risk HPVs that are capable of causing cervical cancer. Many recent studies have demonstrated a high incidence of HPV persistence during post-conization or loop electrosurgical excision (LEEP) due to high-grade cervical intraepithelial neoplasia (CIN). In this report, we correlated the post-operative HPV status with pre-operative HPV type, types of surgery and HPVs physical status. Post-operative HPV E6 amplification by nested PCR was carried out for 157 female patients with positive pre-operative HPV. They underwent LEEPs, therapeutic laser conizations, and simple or radical hysterectomies. We found that high-risk types of HPVs were eradicated in 26.4% (42/159) of patients after extirpation of the lesions. The clearance rate of HPVs increased to 39.2% (40/102), excluding patients with other high-risk (OHR) kinds of type 31, 52b and 58, since OHR persisted after almost all surgeries. Eradication of HPV after radical hysterectomies are highly expected for patients with invasive cancer (70.0%, when excluding OHR), while more than half of them with CIN continue to carry pre-operative types of HPV or some different types from before treatment. Type 33 is most frequently persistent among types 16, 18 and 33. Persistent high-risk HPVs increase the risk for recurrence of post-surgical treatments of CFN, but the incidence is not high as long as the lesion is completely removed.

KW - Cervical cancer

KW - Cervical dysplasia

KW - Eradication

KW - Human papillomavirus

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=16544371320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16544371320&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 375

EP - 379

JO - Oncology Reports

JF - Oncology Reports

SN - 1021-335X

IS - 2

ER -