Equivalence of the acute cytokine surge and myocardial injury after coronary artery bypass grafting with and without a novel extracorporeal circulation system

T. Murakami, H. Iwagaki, S. Saito, S. Ohtani, K. Kuroki, M. Kuinose, N. Tanaka, K. Tanemoto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cardiopulmonary bypass (CPB) contributes to a morbidity-inducing systemic inflammatory response after cardiac surgery. We compared this response in patients receiving coronary artery bypass grafting (CABG) with (CPB group; n = 7) or without (off-pump group; n = 8) the Minimal Extracorporeal Circulation (MECC®) system. Serum concentrations of tumour necrosis factor (TNF)-α, soluble TNF receptors, pro-and anti-inflammatory interleukins (ILs) and other myocardial injury markers were measured after anaesthetic induction, at 1 h, 4 h and 24 h after completing all anastomoses or serially. Soluble TNF receptor type I (sTNFRI) and IL-8 peaked early after CABG in both groups and did not decline. Serum sTNFRI was significantly higher in the CPB compared with the off-pump group at 1 h, whereas IL-8 was significantly lower in the CPB group throughout. The MECC® system, therefore, produces an equivalent acute cytokine response and degree of myocardial injury to off-pump CABG, and may be useful when CABG cannot be performed without CPB.

Original languageEnglish
Pages (from-to)133-149
Number of pages17
JournalJournal of International Medical Research
Volume33
Issue number2
DOIs
Publication statusPublished - 2005

Keywords

  • Complement activation
  • Coronary artery bypass grafting
  • Creatine kinase
  • Cytokines
  • Leucocyte elastase
  • Minimal extracorporeal circulation system
  • Troponin-T

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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