Abstract
Cardiopulmonary bypass (CPB) contributes to a morbidity-inducing systemic inflammatory response after cardiac surgery. We compared this response in patients receiving coronary artery bypass grafting (CABG) with (CPB group; n = 7) or without (off-pump group; n = 8) the Minimal Extracorporeal Circulation (MECC®) system. Serum concentrations of tumour necrosis factor (TNF)-α, soluble TNF receptors, pro-and anti-inflammatory interleukins (ILs) and other myocardial injury markers were measured after anaesthetic induction, at 1 h, 4 h and 24 h after completing all anastomoses or serially. Soluble TNF receptor type I (sTNFRI) and IL-8 peaked early after CABG in both groups and did not decline. Serum sTNFRI was significantly higher in the CPB compared with the off-pump group at 1 h, whereas IL-8 was significantly lower in the CPB group throughout. The MECC® system, therefore, produces an equivalent acute cytokine response and degree of myocardial injury to off-pump CABG, and may be useful when CABG cannot be performed without CPB.
| Original language | English |
|---|---|
| Pages (from-to) | 133-149 |
| Number of pages | 17 |
| Journal | Journal of International Medical Research |
| Volume | 33 |
| Issue number | 2 |
| Publication status | Published - Mar 2005 |
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Keywords
- Complement activation
- Coronary artery bypass grafting
- Creatine kinase
- Cytokines
- Leucocyte elastase
- Minimal extracorporeal circulation system
- Troponin-T
ASJC Scopus subject areas
- Medicine(all)
Cite this
Equivalence of the acute cytokine surge and myocardial injury after coronary artery bypass grafting with and without a novel extracorporeal circulation system. / Murakami, T.; Iwagaki, H.; Saito, Shinya; Ohtani, S.; Kuroki, K.; Kuinose, M.; Tanaka, N.; Tanemoto, K.
In: Journal of International Medical Research, Vol. 33, No. 2, 03.2005, p. 133-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Equivalence of the acute cytokine surge and myocardial injury after coronary artery bypass grafting with and without a novel extracorporeal circulation system
AU - Murakami, T.
AU - Iwagaki, H.
AU - Saito, Shinya
AU - Ohtani, S.
AU - Kuroki, K.
AU - Kuinose, M.
AU - Tanaka, N.
AU - Tanemoto, K.
PY - 2005/3
Y1 - 2005/3
N2 - Cardiopulmonary bypass (CPB) contributes to a morbidity-inducing systemic inflammatory response after cardiac surgery. We compared this response in patients receiving coronary artery bypass grafting (CABG) with (CPB group; n = 7) or without (off-pump group; n = 8) the Minimal Extracorporeal Circulation (MECC®) system. Serum concentrations of tumour necrosis factor (TNF)-α, soluble TNF receptors, pro-and anti-inflammatory interleukins (ILs) and other myocardial injury markers were measured after anaesthetic induction, at 1 h, 4 h and 24 h after completing all anastomoses or serially. Soluble TNF receptor type I (sTNFRI) and IL-8 peaked early after CABG in both groups and did not decline. Serum sTNFRI was significantly higher in the CPB compared with the off-pump group at 1 h, whereas IL-8 was significantly lower in the CPB group throughout. The MECC® system, therefore, produces an equivalent acute cytokine response and degree of myocardial injury to off-pump CABG, and may be useful when CABG cannot be performed without CPB.
AB - Cardiopulmonary bypass (CPB) contributes to a morbidity-inducing systemic inflammatory response after cardiac surgery. We compared this response in patients receiving coronary artery bypass grafting (CABG) with (CPB group; n = 7) or without (off-pump group; n = 8) the Minimal Extracorporeal Circulation (MECC®) system. Serum concentrations of tumour necrosis factor (TNF)-α, soluble TNF receptors, pro-and anti-inflammatory interleukins (ILs) and other myocardial injury markers were measured after anaesthetic induction, at 1 h, 4 h and 24 h after completing all anastomoses or serially. Soluble TNF receptor type I (sTNFRI) and IL-8 peaked early after CABG in both groups and did not decline. Serum sTNFRI was significantly higher in the CPB compared with the off-pump group at 1 h, whereas IL-8 was significantly lower in the CPB group throughout. The MECC® system, therefore, produces an equivalent acute cytokine response and degree of myocardial injury to off-pump CABG, and may be useful when CABG cannot be performed without CPB.
KW - Complement activation
KW - Coronary artery bypass grafting
KW - Creatine kinase
KW - Cytokines
KW - Leucocyte elastase
KW - Minimal extracorporeal circulation system
KW - Troponin-T
UR - http://www.scopus.com/inward/record.url?scp=14944349706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14944349706&partnerID=8YFLogxK
M3 - Article
C2 - 15790125
AN - SCOPUS:14944349706
VL - 33
SP - 133
EP - 149
JO - Journal of International Medical Research
JF - Journal of International Medical Research
SN - 0300-0605
IS - 2
ER -