Equivalence of the acute cytokine surge and myocardial injury after coronary artery bypass grafting with and without a novel extracorporeal circulation system

T. Murakami, H. Iwagaki, Shinya Saito, S. Ohtani, K. Kuroki, M. Kuinose, N. Tanaka, K. Tanemoto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cardiopulmonary bypass (CPB) contributes to a morbidity-inducing systemic inflammatory response after cardiac surgery. We compared this response in patients receiving coronary artery bypass grafting (CABG) with (CPB group; n = 7) or without (off-pump group; n = 8) the Minimal Extracorporeal Circulation (MECC®) system. Serum concentrations of tumour necrosis factor (TNF)-α, soluble TNF receptors, pro-and anti-inflammatory interleukins (ILs) and other myocardial injury markers were measured after anaesthetic induction, at 1 h, 4 h and 24 h after completing all anastomoses or serially. Soluble TNF receptor type I (sTNFRI) and IL-8 peaked early after CABG in both groups and did not decline. Serum sTNFRI was significantly higher in the CPB compared with the off-pump group at 1 h, whereas IL-8 was significantly lower in the CPB group throughout. The MECC® system, therefore, produces an equivalent acute cytokine response and degree of myocardial injury to off-pump CABG, and may be useful when CABG cannot be performed without CPB.

Original languageEnglish
Pages (from-to)133-149
Number of pages17
JournalJournal of International Medical Research
Volume33
Issue number2
Publication statusPublished - Mar 2005

Fingerprint

Extracorporeal Circulation
Cardiopulmonary Bypass
Coronary Artery Bypass
Cytokines
Tumor Necrosis Factor Receptors
Wounds and Injuries
Pumps
Interleukin-8
Receptors, Tumor Necrosis Factor, Type I
Interleukins
Off-Pump Coronary Artery Bypass
Surgery
Anesthetics
Serum
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Thoracic Surgery
Morbidity

Keywords

  • Complement activation
  • Coronary artery bypass grafting
  • Creatine kinase
  • Cytokines
  • Leucocyte elastase
  • Minimal extracorporeal circulation system
  • Troponin-T

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Equivalence of the acute cytokine surge and myocardial injury after coronary artery bypass grafting with and without a novel extracorporeal circulation system. / Murakami, T.; Iwagaki, H.; Saito, Shinya; Ohtani, S.; Kuroki, K.; Kuinose, M.; Tanaka, N.; Tanemoto, K.

In: Journal of International Medical Research, Vol. 33, No. 2, 03.2005, p. 133-149.

Research output: Contribution to journalArticle

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AU - Kuinose, M.

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