Epstein-Barr virus-associated primary central nervous system lymphomas in immunocompetent elderly patients: Analysis for latent membrane protein-1 oncogene deletion and EBNA-2 strain typing

Yasuo Sugita, Mizuhiko Terasaki, Daisuke Niino, Koichi Ohshima, Arakawa Fumiko, Minoru Shigemori, Yasuharu Sato, Naoko Asano

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) has been implicated in the pathogenesis of primary central nervous system lymphomas (PCNLs) in immunocompetent hosts. To investigate the role of EBV in the pathogenesis of PCNLs in immunocompetent hosts, this study assessed six PCNL cases (elderly male immunocompetent patients; age ≥60 years) histologically and immunohistochemically, and an EBV genetic study was performed. Histologically, all cases were diagnosed as diffuse large B-cell lymphoma with extensive necrosis. In all six cases, PCNL cells showed immunohistochemical positivity for latent membrane protein 1 (LMP-1) and Epstein-Barr nuclear 2 (EBNA2). Lymphoma cells also showed positive signals for EBV-encoded small RNAs (EBERs) on in-situ hybridization. EBV subtyping-PCR analysis demonstrated that one case was EBNA 2B type and the other five cases were EBNA 2A type, and two cases were EBV wild-type and four cases showed 30-bp LMP-1 deletion by PCR analysis. It is therefore possible that LMP gene deletion or EBNA-2 strain type are important in the tumorigenesis of EBV-positive PCNLs. In addition, EBV-positive PCNLs in immunocompetent hosts may be related to immunological deterioration derived from the aging process.

Original languageEnglish
Pages (from-to)271-279
Number of pages9
JournalJournal of neuro-oncology
Volume100
Issue number2
DOIs
Publication statusPublished - Nov 2010

Keywords

  • EBNA-2 strain typing
  • Epstein-Barr virus
  • Immunocompetent host
  • Latent membrane protein-1 oncogene deletion
  • Primary central nervous system lymphoma

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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