Epstein-Barr virus associated diffuse large B-cell lymphoma complicated by autoimmune hemolytic anemia and pure red cell aplasia

H. Katayama, M. Takeuchi, T. Yoshino, M. Munemasa, A. Tada, R. Soda, K. Takahashi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A 53-year old man with systemic lymphadenopathy and hepatosplenomegaly was diagnosed with diffuse large B cell-lymphoma after inguinal lymph node biopsy. Anemia was noted, direct and indirect Coombs tests were positive, and the haptoglobin level was low. However, the bone marrow aspirate revealed erythroid aplasia. Co-existing autoimmune haemolytic anemia (AIHA) and pure red cell aplasia (PRCA) were diagnosed. In situ hybridization with Epstein-Barr virus (EBV) encoded small RNA (EBER) showed positive findings in lymphoma cells. Southern blot hybridization revealed immunoglobulin heavy chain gene rearrangement and a clonal EBV terminal repeat, indicating monoclonal proliferation of EBV in infected B cells. The patient was treated with CHOP, resulting in a complete remission (CR). AIHA and PRCA subsided after 3 courses of chemotherapy. In conclusion, this case demonstrates not only the association of B-cell lymphoma with autoimmune disorders but also the involvement of EBV in these conditions.

Original languageEnglish
Pages (from-to)539-542
Number of pages4
JournalLeukemia and Lymphoma
Volume42
Issue number3
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

Keywords

  • Autoimmune haemolytic anemia
  • Diffuse large B cell-lymphoma
  • Epstein-Barr virus
  • Pure red cell aplasia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Epstein-Barr virus associated diffuse large B-cell lymphoma complicated by autoimmune hemolytic anemia and pure red cell aplasia'. Together they form a unique fingerprint.

  • Cite this