Epoprostenol infusion therapy changes angiographic findings of pulmonary arteries in patients with idiopathic pulmonary arterial hypertension

Masahito Sakuma, Jun Demachi, Jun Nawata, Jun Suzuki, Tohru Takahashi, Hiromi Matsubara, Satoshi Akagi, Kunio Shirato

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background The pulmonary vascular changes induced by epoprostenol in patients with idiopathic pulmonary artery hypertension (IPAH) have not been reported by a clinical study. Methods and Results Analysis 1 compared the wedged pulmonary angiography (PAG) findings prior to initiation of epoprostenol therapy (n = 24) with those after initiation (n = 16). Analysis 2 compared the PAG findings prior to and after initiation of epoprostenol therapy (n = 9) in the saine pulmonary arteries in the same subjects. In analysis 1, a "cotton grass-like" stain originating from the peripheral pulmonary vessels (each vessel could not be distinguished on angiography) was not observable in any of 24 cases before initiation of epoprostenol therapy, but was visible in 13 of 16 cases after (p

Original languageEnglish
Pages (from-to)1147-1151
Number of pages5
JournalCirculation Journal
Volume72
Issue number7
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Epoprostenol
Pulmonary Artery
Lung
Angiography
Therapeutics
Poaceae
Blood Vessels
Coloring Agents
Familial Primary Pulmonary Hypertension

Keywords

  • Neovascularization
  • Pulmonary arteriovenous fistula
  • Vasoconstriction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Epoprostenol infusion therapy changes angiographic findings of pulmonary arteries in patients with idiopathic pulmonary arterial hypertension. / Sakuma, Masahito; Demachi, Jun; Nawata, Jun; Suzuki, Jun; Takahashi, Tohru; Matsubara, Hiromi; Akagi, Satoshi; Shirato, Kunio.

In: Circulation Journal, Vol. 72, No. 7, 2008, p. 1147-1151.

Research output: Contribution to journalArticle

Sakuma, Masahito ; Demachi, Jun ; Nawata, Jun ; Suzuki, Jun ; Takahashi, Tohru ; Matsubara, Hiromi ; Akagi, Satoshi ; Shirato, Kunio. / Epoprostenol infusion therapy changes angiographic findings of pulmonary arteries in patients with idiopathic pulmonary arterial hypertension. In: Circulation Journal. 2008 ; Vol. 72, No. 7. pp. 1147-1151.
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