Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome

Wataru Shimizu, Takashi Noda, Hiroshi Takaki, Takashi Kurita, Noritoshi Nagaya, Kazuhiro Satomi, Kazuhiro Suyama, Naohiko Aihara, Shiro Kamakura, Kenji Sunagawa, Shigeyuki Echigo, Kazufumi Nakamura, Tohru Ohe, Jeffrey A. Towbin, Carlo Napolitano, Silvia G. Priori

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Abstract

OBJECTIVES: This study was designed to test the hypothesis that epinephrine infusion may be a provocative test able to unmask nonpenetrant KCNQ1 mutation carriers. BACKGROUND: The LQT1 form of congenital long QT syndrome is associated with high vulnerability to sympathetic stimulation and appears with incomplete penetrance. METHODS: The 12-lead electrocardiographic parameters before and after epinephrine infusion were compared among 19 mutation carriers with a baseline corrected QT interval (QTc) of ≥460 ms (Group I), 15 mutation carriers with a QTc of

Original languageEnglish
Pages (from-to)633-642
Number of pages10
JournalJournal of the American College of Cardiology
Volume41
Issue number4
DOIs
Publication statusPublished - Feb 19 2003

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Long QT Syndrome
Epinephrine
Mutation
Penetrance

ASJC Scopus subject areas

  • Nursing(all)

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Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome. / Shimizu, Wataru; Noda, Takashi; Takaki, Hiroshi; Kurita, Takashi; Nagaya, Noritoshi; Satomi, Kazuhiro; Suyama, Kazuhiro; Aihara, Naohiko; Kamakura, Shiro; Sunagawa, Kenji; Echigo, Shigeyuki; Nakamura, Kazufumi; Ohe, Tohru; Towbin, Jeffrey A.; Napolitano, Carlo; Priori, Silvia G.

In: Journal of the American College of Cardiology, Vol. 41, No. 4, 19.02.2003, p. 633-642.

Research output: Contribution to journalArticle

Shimizu, W, Noda, T, Takaki, H, Kurita, T, Nagaya, N, Satomi, K, Suyama, K, Aihara, N, Kamakura, S, Sunagawa, K, Echigo, S, Nakamura, K, Ohe, T, Towbin, JA, Napolitano, C & Priori, SG 2003, 'Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome', Journal of the American College of Cardiology, vol. 41, no. 4, pp. 633-642. https://doi.org/10.1016/S0735-1097(02)02850-4
Shimizu, Wataru ; Noda, Takashi ; Takaki, Hiroshi ; Kurita, Takashi ; Nagaya, Noritoshi ; Satomi, Kazuhiro ; Suyama, Kazuhiro ; Aihara, Naohiko ; Kamakura, Shiro ; Sunagawa, Kenji ; Echigo, Shigeyuki ; Nakamura, Kazufumi ; Ohe, Tohru ; Towbin, Jeffrey A. ; Napolitano, Carlo ; Priori, Silvia G. / Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome. In: Journal of the American College of Cardiology. 2003 ; Vol. 41, No. 4. pp. 633-642.
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AU - Noda, Takashi

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AU - Satomi, Kazuhiro

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