Abstract
The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.
| Original language | English |
|---|---|
| Pages (from-to) | 258-261 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 991 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Nov 21 2003 |
Keywords
- Amygdala-kindled rat
- Diphenhydramine
- Epileptogenic activity
- Ketotifen
- Pyrilamine
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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Fujii, Y., Tanaka, T., Harada, C., Hirai, T., & Kamei, C. (2003). Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats. Brain Research, 991(1-2), 258-261. https://doi.org/10.1016/j.brainres.2003.08.009