Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats

Yoko Fujii, Takehiro Tanaka, Chie Harada, Tadashi Hirai, Chiaki Kamei

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.

Original languageEnglish
Pages (from-to)258-261
Number of pages4
JournalBrain Research
Volume991
Issue number1-2
DOIs
Publication statusPublished - Nov 21 2003

Fingerprint

Histamine H1 Antagonists
Amygdala
Seizures
Electroencephalography
Loratadine
Cetirizine
Ketotifen
Pyrilamine
Diphenhydramine
Intraperitoneal Injections

Keywords

  • Amygdala-kindled rat
  • Diphenhydramine
  • Epileptogenic activity
  • Ketotifen
  • Pyrilamine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats. / Fujii, Yoko; Tanaka, Takehiro; Harada, Chie; Hirai, Tadashi; Kamei, Chiaki.

In: Brain Research, Vol. 991, No. 1-2, 21.11.2003, p. 258-261.

Research output: Contribution to journalArticle

Fujii, Yoko ; Tanaka, Takehiro ; Harada, Chie ; Hirai, Tadashi ; Kamei, Chiaki. / Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats. In: Brain Research. 2003 ; Vol. 991, No. 1-2. pp. 258-261.
@article{11a0968be4a046e5bcff5ed609a711f9,
title = "Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats",
abstract = "The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.",
keywords = "Amygdala-kindled rat, Diphenhydramine, Epileptogenic activity, Ketotifen, Pyrilamine",
author = "Yoko Fujii and Takehiro Tanaka and Chie Harada and Tadashi Hirai and Chiaki Kamei",
year = "2003",
month = "11",
day = "21",
doi = "10.1016/j.brainres.2003.08.009",
language = "English",
volume = "991",
pages = "258--261",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats

AU - Fujii, Yoko

AU - Tanaka, Takehiro

AU - Harada, Chie

AU - Hirai, Tadashi

AU - Kamei, Chiaki

PY - 2003/11/21

Y1 - 2003/11/21

N2 - The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.

AB - The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.

KW - Amygdala-kindled rat

KW - Diphenhydramine

KW - Epileptogenic activity

KW - Ketotifen

KW - Pyrilamine

UR - http://www.scopus.com/inward/record.url?scp=0142027094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142027094&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2003.08.009

DO - 10.1016/j.brainres.2003.08.009

M3 - Article

C2 - 14575901

AN - SCOPUS:0142027094

VL - 991

SP - 258

EP - 261

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -