Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats

Yoko Fujii, Takehiro Tanaka, Chie Harada, Tadashi Hirai, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.

Original languageEnglish
Pages (from-to)258-261
Number of pages4
JournalBrain Research
Issue number1-2
Publication statusPublished - Nov 21 2003


  • Amygdala-kindled rat
  • Diphenhydramine
  • Epileptogenic activity
  • Ketotifen
  • Pyrilamine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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