Abstract
The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.
| Original language | English |
|---|---|
| Pages (from-to) | 258-261 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 991 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Nov 21 2003 |
Fingerprint
Keywords
- Amygdala-kindled rat
- Diphenhydramine
- Epileptogenic activity
- Ketotifen
- Pyrilamine
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Cite this
Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats. / Fujii, Yoko; Tanaka, Takehiro; Harada, Chie; Hirai, Tadashi; Kamei, Chiaki.
In: Brain Research, Vol. 991, No. 1-2, 21.11.2003, p. 258-261.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats
AU - Fujii, Yoko
AU - Tanaka, Takehiro
AU - Harada, Chie
AU - Hirai, Tadashi
AU - Kamei, Chiaki
PY - 2003/11/21
Y1 - 2003/11/21
N2 - The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.
AB - The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.
KW - Amygdala-kindled rat
KW - Diphenhydramine
KW - Epileptogenic activity
KW - Ketotifen
KW - Pyrilamine
UR - http://www.scopus.com/inward/record.url?scp=0142027094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0142027094&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2003.08.009
DO - 10.1016/j.brainres.2003.08.009
M3 - Article
C2 - 14575901
AN - SCOPUS:0142027094
VL - 991
SP - 258
EP - 261
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -