Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin and its inhibition by a calcium antagonist, nicardipine

Chiaki Kamei, Yukio Sugimoto, Hiroko Ohishi, Yasushi Okumura, Kazuhiro Kitazumi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin was investigated in chronic electrode-implanted rats. Ferubinac ethyl and aspirin DL-lysine showed a spike or spike and wave complex in EEG without showing remarkable behavioral changes when they were injected intraventricularly, although a relatively high dose was needed. Enoxacin, on the other hand, elicited potent epileptogenic activity characterized by uninterrupted high voltage spike and wave complex at doses of 50 and 100 μg. At the same time, rats showed hyperactivity, jumping and violent convulsion. Combined treatment with enoxacin (p.o.) and ferubinac ethyl (i.v.) caused potent epileptogenic activity characterized by uninterrupted burst of high voltage spike and wave complex. Behaviorally, animals showed forelimb clonus, head nodding and generalized convulsion. High voltage spike and wave complex was also observed afer combined treatment with enoxacin (i. vent.) and ferubinac ethyl (i.v. or i. vent.) in association with hyperactivity and jumping and violent convulsion. Nicardipine remarkably inhibited epileptic seizures induced by combined treatment with enoxacin (p.o.) and ferubinac ethyl (i.v.). It is concluded that simultaneous treatment with enoxacin and ferubinac ethyl produced epileptogenic activity when injected intraventricularly, and nicardipine inhibited convulsions induced by combined use of enoxacin (p.o.) and ferubinac ethyl (i.v.).

Original languageEnglish
Pages (from-to)579-588
Number of pages10
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume18
Issue number9
Publication statusPublished - Dec 1 1996

Keywords

  • aspirin DL-lysine
  • enoxacin
  • epileptogenic activity
  • ferubinac ethyl
  • nicardipine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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