(-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes

Haitao Wu, Tomoko Yokoyama, Beiwei Zhu, Yasuaki Shimoishi, Yoshiyuki Murata, Yoshimasa Nakamura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

(-)-Epigallocatechin-3-gallate (EGCG)-induced apoptosis was along both the extracellular signal-regulated protein kinase (ERK) and c-jun N-terminal kinase (JNK) pathways in Jurkat cells. Co-treatment with EGCG potentiated the cytotoxicity induced by benzyl isothiocyanate (BITC) and H2O 2, both being inhibited by ERK and JNK inhibitors. These results suggest the significant role of mitogen-activated protein kinase (MAPK) signaling in the apoptosis induction regulated by EGCG alone and in combination.

Original languageEnglish
Pages (from-to)3034-3037
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number11
DOIs
Publication statusPublished - 2008

Fingerprint

T-cells
Cytotoxicity
Hydrogen Peroxide
T-Lymphocytes
Apoptosis
Jurkat Cells
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Protein Kinases
Phosphotransferases
epigallocatechin gallate
benzyl isothiocyanate

Keywords

  • (-)-epigallocatechin-3-gallate (EGCG)
  • Apoptosis
  • c-jun N-terminal kinase (JNK)
  • Extracellular signal-regulated protein kinase (ERK)
  • Jurkat cells

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

(-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes. / Wu, Haitao; Yokoyama, Tomoko; Zhu, Beiwei; Shimoishi, Yasuaki; Murata, Yoshiyuki; Nakamura, Yoshimasa.

In: Bioscience, Biotechnology and Biochemistry, Vol. 72, No. 11, 2008, p. 3034-3037.

Research output: Contribution to journalArticle

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AU - Murata, Yoshiyuki

AU - Nakamura, Yoshimasa

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