Epidermal antigens and complement‐binding anti‐intercellular antibodies in pemphigus vegetans, Hallopeau type

H. HASHIZUME, K. IWATSUKI, M. TAKIGAWA

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Abstract

The serum of a 34‐year‐old woman with the Hallopeau type of pemphigus vegetans (PVg) contained antibodies against a 130‐kDa polypeptide in human epidermal lysates. as revealed by Western blot analysis. The serum strongly fixed complement in vitro, and the PVg lesional skin contained a predomanance of complement‐fixing IgG2 and lgG4. Although the antigeus reactive with sera from PVg and pemphigus vulgaris were the same strong fixation of complement by PVg antibodies, due to the presence of complement‐dependent IgG subclasses, and subsequent in situ activation of complement might explain the marked infiltration of neutrophils and eosinophils in PVg.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalBritish Journal of Dermatology
Volume129
Issue number6
DOIs
Publication statusPublished - Dec 1993

ASJC Scopus subject areas

  • Dermatology

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