Epidemiology and drug susceptibility of Pseudomonas aeruginosa strains isolated in the Chugoku region of Japan: Infection forum in the Chugoku Region

Masao Kuwabara, Nobuchika Kusano, Eiji Shimizu, Wataru Shimizu, Kanao Kobayashi, Shuntaro Koda, Masao Doi, Motoyuki Sugai, Hiromi Kumon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recently, there have been reports concerning an increased frequency of isolation of multi-drug resistant Pseudomonas aeruginosa (MDRP) strains in hospitals and other clinical settings as well as the associated risk of their hospital-acquired infections; in such a situation, it has been a major challenge to establish methods of managing and treating the infections. In order to investigate the trend of P. aeruginosa, the Infection Forum in the Chugoku Region has conducted to a multi-center collaborative study to isolate P. aeruginosa strains from sputum and urine samples collected between October 2006 and September 2008, analyzed the drug susceptibility and the pulsed-field gel electrophoresis (PFGE) patterns of each strain, and assessed epidemiologic characteristics. Of the 738 P. aeruginosa strains collected in this study, 152 (20.6%), 179 (24.3%), 47 (6.4%), and 39 (5.3%) were found to be ciprofloxacin-resistant, imipenem-resistant, amikacin-resistant, and MDRP, respectively. Among the various antimicrobial agents tested, arbekacin (ABK) revealed the strongest inhibitory effects on each drug-resistant and MDRP strain; therefore, ABK was considered as a potential candidate for future treatment of diseases caused by P aeruginosa. The study also showed that the detection rates of MDRP varied a lot from hospital to hospital. In addition, PFGE-based cluster analyses revealed several strains isolated in the same hospital exhibited a similar PFGE pattern and the same drug susceptibility, suggesting the presence of "unique" hospital-specific strains.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalJapanese Journal of Antibiotics
Volume64
Issue number2
Publication statusPublished - Apr 2011

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Pseudomonas aeruginosa
Japan
Epidemiology
Infection
Pulsed Field Gel Electrophoresis
Pharmaceutical Preparations
Pseudomonas Infections
Amikacin
Imipenem
Ciprofloxacin
Cross Infection
Anti-Infective Agents
Sputum
Cluster Analysis
Urine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Epidemiology and drug susceptibility of Pseudomonas aeruginosa strains isolated in the Chugoku region of Japan : Infection forum in the Chugoku Region. / Kuwabara, Masao; Kusano, Nobuchika; Shimizu, Eiji; Shimizu, Wataru; Kobayashi, Kanao; Koda, Shuntaro; Doi, Masao; Sugai, Motoyuki; Kumon, Hiromi.

In: Japanese Journal of Antibiotics, Vol. 64, No. 2, 04.2011, p. 97-108.

Research output: Contribution to journalArticle

Kuwabara, Masao ; Kusano, Nobuchika ; Shimizu, Eiji ; Shimizu, Wataru ; Kobayashi, Kanao ; Koda, Shuntaro ; Doi, Masao ; Sugai, Motoyuki ; Kumon, Hiromi. / Epidemiology and drug susceptibility of Pseudomonas aeruginosa strains isolated in the Chugoku region of Japan : Infection forum in the Chugoku Region. In: Japanese Journal of Antibiotics. 2011 ; Vol. 64, No. 2. pp. 97-108.
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