Epidemiological study on the relationship between toxin production and psm-mec mutations in MRSA isolates in Thailand

Fumiaki Tabuchi, Aroonlug Lulitanond, Viraphong Lulitanond, Sudaluck Thunyaharn, Chikara Kaito

Research output: Contribution to journalArticle

Abstract

In this present study, we investigated the phenol-soluble modulin (psm-mec) mutations, the staphylococcal cassette chromosome mec (SCCmec) types, and toxin production in 102 methicillin-resistant Staphylococcus aureus (MRSA) isolates from the northeast and central regions of Thailand. The MRSA isolates carrying -7T>C psm-mec in Type II SCCmec (n = 18) and the MRSA isolates carrying no psm-mec in Type IV (n = 8) or Type IX SCCmec (n = 4) had higher hemolytic activity against sheep erythrocytes than MRSA isolates carrying intact psm-mec in Type III SCCmec (n = 34), but MRSA isolates carrying no psm-mec in Type I SCCmec (n = 27) did not.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalMICROBIOLOGY and IMMUNOLOGY
Volume64
Issue number3
DOIs
Publication statusPublished - Mar 1 2020

Keywords

  • MRSA
  • SCCmec
  • psm-mec
  • toxin
  • virulence

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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