Epidemiological studies of neurological signs and symptoms and blood pressure in populations near the industrial methylmercury contamination at Minamata, Japan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Severe methylmercury exposure occurred in Minamata, Japan. Only a limited number of epidemiological studies related to that exposure have been carried out. The evidence that methylmercury is cardiotoxic is very limited, and these studies provide only minimal support for that hypothesis. We therefore analyzed the data both from an investigation in Minamata and neighboring communities in 1971 and an investigation in 1974 in another area simultaneously. We included a total of 3,751 participants. We examined the association of residential area with neurological signs or blood pressure using logistic regression or multiple linear regression models, adjusting for sex and age. We found that the prevalence of neurological signs and symptoms was elevated in the Minamata area (high-exposure), followed by the Goshonoura area (medium-exposure). Moreover, blood pressure was elevated in residents of the Minamata area.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalArchives of Environmental and Occupational Health
DOIs
Publication statusAccepted/In press - Feb 15 2016

Fingerprint

Blood pressure
methylmercury
Signs and Symptoms
Epidemiologic Studies
Linear Models
Japan
Contamination
blood
Blood Pressure
Linear regression
Population
Logistics
Logistic Models
logistics
exposure
contamination

Keywords

  • Epidemiological studies
  • hypertension
  • methylmercury poisoning
  • Minamata disease
  • neurological signs

ASJC Scopus subject areas

  • Environmental Science(all)
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Public Health, Environmental and Occupational Health

Cite this

@article{36c47bf77cc44de7b39741074f649d2c,
title = "Epidemiological studies of neurological signs and symptoms and blood pressure in populations near the industrial methylmercury contamination at Minamata, Japan",
abstract = "Severe methylmercury exposure occurred in Minamata, Japan. Only a limited number of epidemiological studies related to that exposure have been carried out. The evidence that methylmercury is cardiotoxic is very limited, and these studies provide only minimal support for that hypothesis. We therefore analyzed the data both from an investigation in Minamata and neighboring communities in 1971 and an investigation in 1974 in another area simultaneously. We included a total of 3,751 participants. We examined the association of residential area with neurological signs or blood pressure using logistic regression or multiple linear regression models, adjusting for sex and age. We found that the prevalence of neurological signs and symptoms was elevated in the Minamata area (high-exposure), followed by the Goshonoura area (medium-exposure). Moreover, blood pressure was elevated in residents of the Minamata area.",
keywords = "Epidemiological studies, hypertension, methylmercury poisoning, Minamata disease, neurological signs",
author = "Takashi Yorifuji and Toshihide Tsuda",
year = "2016",
month = "2",
day = "15",
doi = "10.1080/19338244.2015.1084261",
language = "English",
pages = "1--6",
journal = "Archives of Environmental and Occupational Health",
issn = "1933-8244",
publisher = "Heldref Publications",

}

TY - JOUR

T1 - Epidemiological studies of neurological signs and symptoms and blood pressure in populations near the industrial methylmercury contamination at Minamata, Japan

AU - Yorifuji, Takashi

AU - Tsuda, Toshihide

PY - 2016/2/15

Y1 - 2016/2/15

N2 - Severe methylmercury exposure occurred in Minamata, Japan. Only a limited number of epidemiological studies related to that exposure have been carried out. The evidence that methylmercury is cardiotoxic is very limited, and these studies provide only minimal support for that hypothesis. We therefore analyzed the data both from an investigation in Minamata and neighboring communities in 1971 and an investigation in 1974 in another area simultaneously. We included a total of 3,751 participants. We examined the association of residential area with neurological signs or blood pressure using logistic regression or multiple linear regression models, adjusting for sex and age. We found that the prevalence of neurological signs and symptoms was elevated in the Minamata area (high-exposure), followed by the Goshonoura area (medium-exposure). Moreover, blood pressure was elevated in residents of the Minamata area.

AB - Severe methylmercury exposure occurred in Minamata, Japan. Only a limited number of epidemiological studies related to that exposure have been carried out. The evidence that methylmercury is cardiotoxic is very limited, and these studies provide only minimal support for that hypothesis. We therefore analyzed the data both from an investigation in Minamata and neighboring communities in 1971 and an investigation in 1974 in another area simultaneously. We included a total of 3,751 participants. We examined the association of residential area with neurological signs or blood pressure using logistic regression or multiple linear regression models, adjusting for sex and age. We found that the prevalence of neurological signs and symptoms was elevated in the Minamata area (high-exposure), followed by the Goshonoura area (medium-exposure). Moreover, blood pressure was elevated in residents of the Minamata area.

KW - Epidemiological studies

KW - hypertension

KW - methylmercury poisoning

KW - Minamata disease

KW - neurological signs

UR - http://www.scopus.com/inward/record.url?scp=84958546028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958546028&partnerID=8YFLogxK

U2 - 10.1080/19338244.2015.1084261

DO - 10.1080/19338244.2015.1084261

M3 - Article

C2 - 26299421

AN - SCOPUS:84958546028

SP - 1

EP - 6

JO - Archives of Environmental and Occupational Health

JF - Archives of Environmental and Occupational Health

SN - 1933-8244

ER -