Eosinophil cationic protein in the nasal secretions of patients with mite allergic rhinitis

Keiko Nishioka, Chisato Saito, Toshiaki Nagano, Mitsuhiro Okano, Yu Masuda, Toyomitsu Kuriyama

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

In 25 patients with mite nasal allergy and 13 healthy control subjects, levels of eosinophil cationic protein (ECP) and histamine in nasal secretions were examined before and after challenge with mite extract. The ECP level was found to be significantly higher in the washings taken 30 minutes after challenge compared with the washings taken before challenge (P <.05). ECP levels measured both before and after mite extract challenge were found to be significantly higher in the patients than in the controls (P <.01). These facts suggest than the ECP affects the nasal mucosa by causing injury to ciliated cells and by acceleration of the processes of modification and inhibition of the allergic reaction.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalLaryngoscope
Volume103
Issue number2
DOIs
Publication statusPublished - Feb 1993

ASJC Scopus subject areas

  • Otorhinolaryngology

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