We have previously isolated cyclo(<small>L</small>-Pro-<small>L</small>-Tyr) and cyclo(<small>L</small>-Phe-<small>L</small>-Pro) from an actinomycete by a novel enzymatic conversion-guided method. Their tetradehydro derivatives, cyclo(ΔPro-ΔTyr) and cyclo(ΔPhe-ΔPro), were enzymatically prepared. Neither of them inhibited cell division, in contrast to other tetradehydro cyclic dipeptides prepared previously. This result suggests that an NH proton in a diketopiperazine ring and/or conformation of the compound are important for the activity.
- dehydro cyclic dipeptide
- enzymatic conversion
- inhibitor of cell division
Arunrattiyakorn, P., Ikeda, B., Nitoda, T., & Kanzaki, H. (2007). Enzymatic Synthesis of Dehydroderivatives from Proline-Containing Cyclic Dipeptides and Their Effects toward Cell Division. Bioscience, Biotechnology and Biochemistry, 71(3), 830-833. https://doi.org/10.1271/bbb.60651