Enzymatic Synthesis of Dehydroderivatives from Proline-Containing Cyclic Dipeptides and Their Effects toward Cell Division

Panarat Arunrattiyakorn, Banri Ikeda, Teruhiko Nitoda, Hiroshi Kanzaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have previously isolated cyclo(<small>L</small>-Pro-<small>L</small>-Tyr) and cyclo(<small>L</small>-Phe-<small>L</small>-Pro) from an actinomycete by a novel enzymatic conversion-guided method. Their tetradehydro derivatives, cyclo(ΔPro-ΔTyr) and cyclo(ΔPhe-ΔPro), were enzymatically prepared. Neither of them inhibited cell division, in contrast to other tetradehydro cyclic dipeptides prepared previously. This result suggests that an NH proton in a diketopiperazine ring and/or conformation of the compound are important for the activity.
Original languageEnglish
Pages (from-to)830-833
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number3
DOIs
Publication statusPublished - Mar 23 2007
Externally publishedYes

Keywords

  • dehydro cyclic dipeptide
  • enzymatic conversion
  • inhibitor of cell division
  • diketopiperazine
  • albonoursin

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