Enzymatic resolution of (±)-epoxy-β-cyclogeraniol, a synthetic precursor for abscisic acid analogs

Ryou Okazaki, Hiromasa Kiyota, Takayuki Oritani

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Lipase-catalyzed optical resolution of (±)-epoxy-β-cyclogeraniol (1), a key synthetic intermediate for epoxy-β-ionylideneacetic acid, was achieved in high enantiomeric purity. Transesterification with vinyl acetate by using lipase P (Nagase) made enriched (-)-1, while hydrolysis of the corresponding acetate by using lipase P (Amano) afforded (+)-1 with a high E value (E=1600).

Original languageEnglish
Pages (from-to)1444-1447
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number7
Publication statusPublished - 2000
Externally publishedYes


  • Abscisic acid
  • Epoxy-β-cyclogeraniol
  • Epoxy-β-ionylideneacetic acid
  • Lipase
  • Transesterification

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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