Abstract
Lipase-catalyzed optical resolution of (±)-epoxy-β-cyclogeraniol (1), a key synthetic intermediate for epoxy-β-ionylideneacetic acid, was achieved in high enantiomeric purity. Transesterification with vinyl acetate by using lipase P (Nagase) made enriched (-)-1, while hydrolysis of the corresponding acetate by using lipase P (Amano) afforded (+)-1 with a high E value (E=1600).
Original language | English |
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Pages (from-to) | 1444-1447 |
Number of pages | 4 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 64 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2000 |
Externally published | Yes |
Keywords
- Abscisic acid
- Epoxy-β-cyclogeraniol
- Epoxy-β-ionylideneacetic acid
- Lipase
- Transesterification
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry