Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6-and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6

Shingo Eikawa, Yoshihiro Ohue, Kenta Kitaoka, Toshiki Aji, Akiko Uenaka, Mikio Oka, Eiichi Nakayama

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Analysis of cytokine and chemokine production by tumor cell lines including five lung cancers, a malignant mesothelioma, and a malignant melanoma recently established in our laboratory showed rather high production of IL-8 in all tumors and IL-6 in one lung cancer, the malignant mesothelioma, and the malignant melanoma. We investigated the migration of PBMCs to these tumor cells using Transwell plates and showed enrichment of Foxp3+ CD4 regulatory T cells (Tregs) in migrated T cells to both IL-6-and IL-8-producing tumors. Marked induction of CXCR1 expression on Foxp3+ CD4 Tregs by IL-6 followed by IL-8-mediated migration appeared to be responsible for enriched migration. Frequent production of IL-8 by the tumors and Treg migration to those tumors through induction of IL-8R expression by IL-6 is one of the mechanisms for tumor escape.

Original languageEnglish
Pages (from-to)6734-6740
Number of pages7
JournalJournal of Immunology
Volume185
Issue number11
DOIs
Publication statusPublished - Dec 1 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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