Enhancement of the efficiency of the low temperature method for kinetic resolution of primary alcohols by optimizing the organic bridges in porous ceramic-immobilized lipase

Takashi Sakai, Kyoko Hayashi, Fumika Yano, Mie Takami, Megumi Ino, Toshinobu Korenaga, Tadashi Ema

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

For the enhancement of enantioselectivity and acceleration of the reaction rate in the lipase-catalyzed resolution of primary alcohols, the use of a very low reaction temperature (-30 °C) and an immobilized lipase on organic bridges-coated porous ceramic support was found to be highly effective. Furthermore, the structure of the organic bridges greatly influenced the temperature effect between in E and 1/T as well as the reaction rate. Among the organic bridges examined in the resolution of (±)-2-hydroxymethyl-1,4-benzodioxane, the 6-(2-methylpropanoyloxy)hexylsilanetrioxyl bridge was the best choice for both the E value and the reaction rate at -30 °C.

Original languageEnglish
Pages (from-to)1441-1446
Number of pages6
JournalBulletin of the Chemical Society of Japan
Volume76
Issue number7
DOIs
Publication statusPublished - Jul 2003

ASJC Scopus subject areas

  • Chemistry(all)

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