Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats

Toshio Kumai, Masami Tanaka, Tomonori Tateishi, Minoru Watanabe, Hironori Nakura, Shinichi Kobayashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated the alteration of tyrosine hydroxylase (TH) mRNA expression and androgen receptor in the adrenal medulla of spontaneously hypertensive rats (SHR). The TH mRNA expression in the adrenal medulla of SHR was higher than that of Wistar Kyoto rats (WKY). The testosterone increased the TH mRNA expression of SHR, but not WKY. The affinity of androgen receptor in the adrenal medulla of SHR was higher than that of WKY; however, the number of androgen receptor was not different. These results suggested that the increased binding affinity of the androgen receptor of SHR may be related to TH gene transcription in the adrenal medulla.

Original languageEnglish
Pages (from-to)1179-1191
Number of pages13
JournalClinical and Experimental Hypertension
Volume19
Issue number8
DOIs
Publication statusPublished - Nov 1997
Externally publishedYes

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Keywords

  • Adrenal medulla
  • Androgen receptor
  • Inbred SHR
  • Rats
  • Tyrosine hydroxylase mRNA

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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