Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites

Tomomi Noguchi, Chihiro Shinji, Hisayoshi Kobayashi, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Thalidomide (Thal: 1) and its two metabolites, 5-hydroxythalidomide (5-HT: 2) and N-hydroxythalidomide (N-HT: 3), showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation. 5-HT and N-HT showed tubulin polymerization-inhibiting activity, but thalidomide did not.

Original languageEnglish
Pages (from-to)563-564
Number of pages2
JournalBiological and Pharmaceutical Bulletin
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 2005
Externally publishedYes

Fingerprint

Thalidomide
HL-60 Cells
Tretinoin
Cell Differentiation
Serotonin
Tubulin
Polymerization
N-hydroxythalidomide
5-hydroxythalidomide

Keywords

  • Differentiation
  • Hydroxythalidomide
  • Retinoic acid
  • Thalidomide
  • Tubulin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites. / Noguchi, Tomomi; Shinji, Chihiro; Kobayashi, Hisayoshi; Makishima, Makoto; Miyachi, Hiroyuki; Hashimoto, Yuichi.

In: Biological and Pharmaceutical Bulletin, Vol. 28, No. 3, 03.2005, p. 563-564.

Research output: Contribution to journalArticle

Noguchi, Tomomi ; Shinji, Chihiro ; Kobayashi, Hisayoshi ; Makishima, Makoto ; Miyachi, Hiroyuki ; Hashimoto, Yuichi. / Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites. In: Biological and Pharmaceutical Bulletin. 2005 ; Vol. 28, No. 3. pp. 563-564.
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