Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites

Tomomi Noguchi, Chihiro Shinji, Hisayoshi Kobayashi, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Thalidomide (Thal: 1) and its two metabolites, 5-hydroxythalidomide (5-HT: 2) and N-hydroxythalidomide (N-HT: 3), showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation. 5-HT and N-HT showed tubulin polymerization-inhibiting activity, but thalidomide did not.

Original languageEnglish
Pages (from-to)563-564
Number of pages2
JournalBiological and Pharmaceutical Bulletin
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 1 2005

Keywords

  • Differentiation
  • Hydroxythalidomide
  • Retinoic acid
  • Thalidomide
  • Tubulin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites'. Together they form a unique fingerprint.

  • Cite this