Enhanced Membrane Permeability to Phenol Red by Medium-Chain Glycerides

Studies on the Membrane Permeability and Microviscosity

Kazutaka Higaki, Muneyoshi Kato, Mitsuru Hashida, Hitoshi Sezaki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To clarify the mechanism of the drug absorption enhancement by medium-chain glycerides (MCG), the changes in membrane permeability provoked by MCG were investigated with liposomal uptake experiments. Uptake of phenol red (PR) into liposomes increased with an increase in MCG content in the liposomal membrane, suggesting that PR absorption was enhanced in the “transcellular route.” However, the apparent membranous microviscosity obtained in fluorescence depolarization studies tended to increase with the addition of MCG in both the hydrophobic core and the polar head regions of the liposomal membrane. Thus, an enhancement in membrane permeability caused by MCG was not accompanied by a decrease in the apparent membranous microviscosity.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalPharmaceutical Research
Volume5
Issue number5
DOIs
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Phenolsulfonphthalein
Glycerides
Permeability
Membranes
Cold Climate
Depolarization
Liposomes
Fluorescence
Pharmaceutical Preparations
Experiments

Keywords

  • cholesterol
  • enhancement of membrane permeability
  • medium-chain glyceride
  • membranous microviscosity
  • phenol red
  • uptake into liposomes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Organic Chemistry
  • Pharmacology (medical)
  • Pharmaceutical Science
  • Pharmacology
  • Chemistry(all)

Cite this

Enhanced Membrane Permeability to Phenol Red by Medium-Chain Glycerides : Studies on the Membrane Permeability and Microviscosity. / Higaki, Kazutaka; Kato, Muneyoshi; Hashida, Mitsuru; Sezaki, Hitoshi.

In: Pharmaceutical Research, Vol. 5, No. 5, 1988, p. 309-312.

Research output: Contribution to journalArticle

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