Enhanced in vivo magnetic resonance imaging of tumors by PEGylated iron-oxide-gold core-shell nanoparticles with prolonged blood circulation properties

Michiaki Kumagai, Tridib Kumar Sarmat, Horacio Cabral, Sachiko Kaida, Masaki Sekino, Nicholas Herlambang, Kensuke Osada, Mitsunobu R. Kano, Nobuhiro Nishiyama, Kazunori Kataoka

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

High-density poly(ethylene glycol) (PEG)-coated iron-oxide-gold core-shell nanoparticles (AuIONs) were developed as T2-weighted magnetic resonance imaging (MRI) contrast agents for cancer imaging. The PEG-coated iron-oxide-gold core-shell nanoparticles (PEGAuIONs) were approximately 25 nm in diameter with a narrow distribution. Biodistribution experiments in mice bearing a subcutaneous colon cancer model prepared with C26 murine colon adenocarcinoma cells showed high accumulation of the PEG-AuIONs within the tumor mass and low nonspecific accumulation in the liver and spleen, resulting in high specificity to solid tumors. T2-weighted MR images following intravenous injection of PEG-AuIONs showed selective negative enhancement of tumor tissue in an orthotopic pancreatic cancer model prepared with MiaPaCa-2 human pancreatic adenocarcinoma cells. These results indicate that PEG-AuIONs are a promising MRI contrast agent for diagnosis of malignant tumors, including pancreatic cancer. (Figure Presented)

Original languageEnglish
Pages (from-to)1521-1528
Number of pages8
JournalMacromolecular Rapid Communications
Volume31
Issue number17
DOIs
Publication statusPublished - Sep 1 2010
Externally publishedYes

Keywords

  • Gold coatings
  • Iron oxide
  • Magnetic resonance imaging
  • Nanoparticles
  • Polyethylene glycol

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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