Enhanced in vivo magnetic resonance imaging of tumors by PEGylated iron-oxide-gold core-shell nanoparticles with prolonged blood circulation properties

Michiaki Kumagai, Tridib Kumar Sarmat, Horacio Cabral, Sachiko Kaida, Masaki Sekino, Nicholas Herlambang, Kensuke Osada, Mitsunobu Kano, Nobuhiro Nishiyama, Kazunori Kataoka

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

High-density poly(ethylene glycol) (PEG)-coated iron-oxide-gold core-shell nanoparticles (AuIONs) were developed as T2-weighted magnetic resonance imaging (MRI) contrast agents for cancer imaging. The PEG-coated iron-oxide-gold core-shell nanoparticles (PEGAuIONs) were approximately 25 nm in diameter with a narrow distribution. Biodistribution experiments in mice bearing a subcutaneous colon cancer model prepared with C26 murine colon adenocarcinoma cells showed high accumulation of the PEG-AuIONs within the tumor mass and low nonspecific accumulation in the liver and spleen, resulting in high specificity to solid tumors. T2-weighted MR images following intravenous injection of PEG-AuIONs showed selective negative enhancement of tumor tissue in an orthotopic pancreatic cancer model prepared with MiaPaCa-2 human pancreatic adenocarcinoma cells. These results indicate that PEG-AuIONs are a promising MRI contrast agent for diagnosis of malignant tumors, including pancreatic cancer. (Figure Presented)

Original languageEnglish
Pages (from-to)1521-1528
Number of pages8
JournalMacromolecular Rapid Communications
Volume31
Issue number17
DOIs
Publication statusPublished - Sep 1 2010
Externally publishedYes

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Keywords

  • Gold coatings
  • Iron oxide
  • Magnetic resonance imaging
  • Nanoparticles
  • Polyethylene glycol

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

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