Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells

R. Tamura, H. K. Takahashi, D. Xue, S. Kubo, S. Saito, M. Nishibori, H. Iwagaki, N. Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-α and interferon-γ. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalJournal of International Medical Research
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 1 2004

Keywords

  • B7.2
  • Bu-Zhong-Yi-Qi-Tang (TJ-41)
  • Co-stimulatory molecule
  • Intercellular adhesion molecule-1 (ICAM-1)
  • Interferon-γ
  • Interleukin-18
  • Tumour necrosis factor-α

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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