Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells

R. Tamura, H. K. Takahashi, D. Xue, S. Kubo, Shinya Saito, Masahiro Nishibori, H. Iwagaki, N. Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-α and interferon-γ. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalJournal of International Medical Research
Volume32
Issue number1
Publication statusPublished - Jan 2004

Fingerprint

Interleukin-18
Interferons
Blood Cells
Blood
Tumor Necrosis Factor-alpha
Intercellular Adhesion Molecule-1
Pathogens
Cellular Immunity
Fluorescence
Molecules
bu-zhong-yi-qi-tang

Keywords

  • B7.2
  • Bu-Zhong-Yi-Qi-Tang (TJ-41)
  • Co-stimulatory molecule
  • Intercellular adhesion molecule-1 (ICAM-1)
  • Interferon-γ
  • Interleukin-18
  • Tumour necrosis factor-α

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{75900811a4f745479a5611b5c58326a9,
title = "Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells",
abstract = "Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-α and interferon-γ. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.",
keywords = "B7.2, Bu-Zhong-Yi-Qi-Tang (TJ-41), Co-stimulatory molecule, Intercellular adhesion molecule-1 (ICAM-1), Interferon-γ, Interleukin-18, Tumour necrosis factor-α",
author = "R. Tamura and Takahashi, {H. K.} and D. Xue and S. Kubo and Shinya Saito and Masahiro Nishibori and H. Iwagaki and N. Tanaka",
year = "2004",
month = "1",
language = "English",
volume = "32",
pages = "25--32",
journal = "Journal of International Medical Research",
issn = "0300-0605",
publisher = "Field House Publishing LLP",
number = "1",

}

TY - JOUR

T1 - Enhanced effects of combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and interleukin-18 on the production of tumour necrosis factor-α and interferon-γ in human peripheral blood mononuclear cells

AU - Tamura, R.

AU - Takahashi, H. K.

AU - Xue, D.

AU - Kubo, S.

AU - Saito, Shinya

AU - Nishibori, Masahiro

AU - Iwagaki, H.

AU - Tanaka, N.

PY - 2004/1

Y1 - 2004/1

N2 - Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-α and interferon-γ. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.

AB - Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-α and interferon-γ. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.

KW - B7.2

KW - Bu-Zhong-Yi-Qi-Tang (TJ-41)

KW - Co-stimulatory molecule

KW - Intercellular adhesion molecule-1 (ICAM-1)

KW - Interferon-γ

KW - Interleukin-18

KW - Tumour necrosis factor-α

UR - http://www.scopus.com/inward/record.url?scp=0742272480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0742272480&partnerID=8YFLogxK

M3 - Article

C2 - 14997702

AN - SCOPUS:0742272480

VL - 32

SP - 25

EP - 32

JO - Journal of International Medical Research

JF - Journal of International Medical Research

SN - 0300-0605

IS - 1

ER -