Enhanced angiogenesis in bFGF-containing scaffold promoted viability of enclosed hepatocytes and maintained hepatospecific glycogen storage capacity

Takayuki Takei, Hiroyuki Ijima, Shinji Sakai, Tsutomu Ono, Koei Kawakami

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We fabricated a scaffold of poly (lactic acid) and acidic gelatin, a sustained-release carrier of basic fibroblast growth factor (bFGF), which is a positive regulator of angiogenesis. After 1 week of implantation into mesentery of rats, blood vessels induced in the bFGF-containing scaffolds were almost double those in the bFGF-free scaffolds. Further, histological examination of hepatocyte-immobilizing scaffolds retrieved after 1 week of implantation into the mesentery of the rats that received a 70% hepatectomy revealed that the bFGF-containing scaffolds were more efficient for immobilized cell survival than the bFGF-free scaffolds. As well, hepatocytes in the bFGF-containing scaffolds kept their hepatospecific glycogen storage capacity.

Original languageEnglish
Pages (from-to)913-917
Number of pages5
JournalJournal of Chemical Engineering of Japan
Volume38
Issue number11
DOIs
Publication statusPublished - Nov 20 2005
Externally publishedYes

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Keywords

  • Angiogenesis
  • bFGF
  • Cell transplantation
  • Hepatocyte
  • Scaffold

ASJC Scopus subject areas

  • Chemical Engineering(all)

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