Engineered bio-nanocapsules, the selective vector for drug delivery system

Dongwei Yu, Takayuki Fukuda, Tuoya, Shun'ichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Tadanori Yamada, Hiroko Tada, Masaharu Seno

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9 Citations (Scopus)

Abstract

The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalIUBMB Life
Volume58
Issue number1
DOIs
Publication statusPublished - Jan 2006

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Keywords

  • Delivery
  • Specific infection
  • Topology
  • Vector

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Yu, D., Fukuda, T., Tuoya, Kuroda, S., Tanizawa, K., Kondo, A., Ueda, M., Yamada, T., Tada, H., & Seno, M. (2006). Engineered bio-nanocapsules, the selective vector for drug delivery system. IUBMB Life, 58(1), 1-6. https://doi.org/10.1080/15216540500484368