Engineered bio-nanocapsules, the selective vector for drug delivery system

Dongwei Yu, Takayuki Fukuda, Tuoya, Shun'ichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Tadanori Yamada, Hiroko Tada, Masaharu Seno

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalIUBMB Life
Issue number1
Publication statusPublished - Jan 1 2006


  • Delivery
  • Specific infection
  • Topology
  • Vector

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology


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