Engineered bio-nanocapsules, the selective vector for drug delivery system

Dongwei Yu; Takayuki Fukuda; Tuoya; Shun'ichi Kuroda; Katsuyuki Tanizawa; Akihiko Kondo; Masakazu Ueda; Tadanori Yamada; Hiroko Tada; Masaharu Seno

doi:10.1080/15216540500484368

Engineered bio-nanocapsules, the selective vector for drug delivery system

Dongwei Yu, Takayuki Fukuda, Tuoya, Shun'ichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Tadanori Yamada, Hiroko Tada, Masaharu Seno

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	IUBMB Life
Volume	58
Issue number	1
DOIs	https://doi.org/10.1080/15216540500484368
Publication status	Published - Jan 1 2006

Keywords

Delivery
Specific infection
Topology
Vector

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics
Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/15216540500484368

Cite this

@article{7f5c913182ad4bd8af01b414d73b525e,

title = "Engineered bio-nanocapsules, the selective vector for drug delivery system",

abstract = "The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.",

keywords = "Delivery, Specific infection, Topology, Vector",

author = "Dongwei Yu and Takayuki Fukuda and Tuoya and Shun'ichi Kuroda and Katsuyuki Tanizawa and Akihiko Kondo and Masakazu Ueda and Tadanori Yamada and Hiroko Tada and Masaharu Seno",

year = "2006",

month = jan,

day = "1",

doi = "10.1080/15216540500484368",

language = "English",

volume = "58",

pages = "1--6",

journal = "Biochemistry and Molecular Biology International",

issn = "1521-6543",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Engineered bio-nanocapsules, the selective vector for drug delivery system

AU - Yu, Dongwei

AU - Fukuda, Takayuki

AU - Tuoya,

AU - Kuroda, Shun'ichi

AU - Tanizawa, Katsuyuki

AU - Kondo, Akihiko

AU - Ueda, Masakazu

AU - Yamada, Tadanori

AU - Tada, Hiroko

AU - Seno, Masaharu

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.

AB - The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.

KW - Delivery

KW - Specific infection

KW - Topology

KW - Vector

UR - http://www.scopus.com/inward/record.url?scp=33645106243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645106243&partnerID=8YFLogxK

U2 - 10.1080/15216540500484368

DO - 10.1080/15216540500484368

M3 - Review article

C2 - 16596748

AN - SCOPUS:33645106243

SN - 1521-6543

VL - 58

SP - 1

EP - 6

JO - Biochemistry and Molecular Biology International

JF - Biochemistry and Molecular Biology International

IS - 1

ER -

Engineered bio-nanocapsules, the selective vector for drug delivery system

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this