Endothelial function is impaired in patients receiving antihypertensive drug treatment regardless of blood pressure level FMD-J study (flow-mediated dilation Japan)

Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Binti Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu NakashimaChikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Itoh, Hisao Ikeda, Akira Yamashina, Yukihito Higashi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hypertension is associated with endothelial dysfunction. Blood pressure significantly correlates with endothelial function in antihypertensive drug-naive subjects. The purpose of this study was to determine whether treatment status affects the relationship between blood pressure and endothelial function. We measured flowmediated vasodilation (FMD) in 2297 subjects, including 1822 antihypertensive drug-naive subjects and 475 treated hypertensive patients. FMD significantly decreased in relation to increase in systolic blood pressure (8.2±3.1% in subjects with systolic blood pressure of <120 mm Hg, 7.5±2.8% for 120-129 mm Hg, 7.1±2.8% for 130-139 mm Hg, and 6.7±2.6% for =140 mm Hg; P<0.001). Systolic blood pressure was independently associated with FMD in untreated subjects. In contrast, there was no significant relationship between systolic blood pressure and FMD in treated hypertensive patients (4.6±3.1% in treated hypertensives with systolic blood pressure of <120 mm Hg, 4.8±2.7% for 120-129 mm Hg, 4.9±2.8% for 130-139 mm Hg, and 4.5±2.3% for =140 mm Hg; P=0.77). Propensity score matching analysis revealed that the prevalence of endothelial dysfunction defined as FMD of less than the division point for the lowest tertile, and the middle tertile of FMD was significantly higher in treated hypertensive patients than in untreated subjects in all systolic blood pressure categories. Endothelial functionassessed by FMD was impaired regardless of the level of blood pressure achieved by antihypertensive drug treatment in hypertensive patients.

Original languageEnglish
Pages (from-to)790-797
Number of pages8
JournalHypertension
Volume70
Issue number4
DOIs
Publication statusPublished - Jan 1 2017

    Fingerprint

Keywords

  • Antihypertensive agents
  • Blood pressure
  • Blood pressure determination
  • Hypertension
  • Vasodilation

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Maruhashi, T., Soga, J., Fujimura, N., Idei, N., Mikami, S., Iwamoto, Y., Iwamoto, A., Kajikawa, M., Matsumoto, T., Oda, N., Kishimoto, S., Matsui, S., Hashimoto, H., Aibara, Y., Yusoff, F. B. M., Hidaka, T., Kihara, Y., Chayama, K., Noma, K., ... Higashi, Y. (2017). Endothelial function is impaired in patients receiving antihypertensive drug treatment regardless of blood pressure level FMD-J study (flow-mediated dilation Japan). Hypertension, 70(4), 790-797. https://doi.org/10.1161/HYPERTENSIONAHA.117.09612