Endothelial dysfunction, increased arterial stiffness, and cardiovascular risk prediction in patients with coronary artery disease

FMD-J (flow-mediated dilation Japan) study A

Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima & 25 others Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Itoh, Hisao Ikeda, Akira Yamashina, Yukihito Higashi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background—The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. Methods and Results—We measured flow-mediated vasodilation (FMD) and brachial–ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow-up period of 49.2 months, the first primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver-operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio, 0.27; 95% confidence interval, 0.06–0.74; P=0.008) and second (hazard ratio, 0.32; 95% confidence interval, 0.09–0.79; P=0.01) primary outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the first (hazard ratio, 1.86; 95% confidence interval, 1.01–3.44; P=0.04) and second (hazard ratio, 2.19; 95% confidence interval, 1.23–3.90; P=0.008) primary outcomes. Among 4 groups stratified according to the combination of cutoff values of FMD and baPWV, stepwise increases in the calculated risk ratio for the first and second primary outcomes were observed. Conclusions—In patients with coronary artery disease, both FMD and baPWV were significant predictors of cardiovascular events. The combination of FMD and baPWV provided further cardiovascular risk stratification. Clinical Trial Registration—URL: www.umin.ac.jp. Unique identifier: UMIN000012950.

Original languageEnglish
Article numbere008588
JournalJournal of the American Heart Association
Volume7
Issue number14
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Pulse Wave Analysis
Vascular Stiffness
Vasodilation
Coronary Artery Disease
Dilatation
Japan
Confidence Intervals
Sudden Death
Multicenter Studies
Observational Studies
Blood Vessels
Heart Failure
Stroke
Odds Ratio
Clinical Trials

Keywords

  • Arterial stiffness
  • Coronary artery disease
  • Endothelial function
  • Flow-induced dilation
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Endothelial dysfunction, increased arterial stiffness, and cardiovascular risk prediction in patients with coronary artery disease : FMD-J (flow-mediated dilation Japan) study A. / Maruhashi, Tatsuya; Soga, Junko; Fujimura, Noritaka; Idei, Naomi; Mikami, Shinsuke; Iwamoto, Yumiko; Iwamoto, Akimichi; Kajikawa, Masato; Matsumoto, Takeshi; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Tomiyama, Hirofumi; Takase, Bonpei; Kohro, Takahide; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Itoh, Hiroshi; Ikeda, Hisao; Yamashina, Akira; Higashi, Yukihito.

In: Journal of the American Heart Association, Vol. 7, No. 14, e008588, 01.07.2018.

Research output: Contribution to journalArticle

Maruhashi, T, Soga, J, Fujimura, N, Idei, N, Mikami, S, Iwamoto, Y, Iwamoto, A, Kajikawa, M, Matsumoto, T, Oda, N, Kishimoto, S, Matsui, S, Hashimoto, H, Aibara, Y, Yusoff, FM, Hidaka, T, Kihara, Y, Chayama, K, Noma, K, Nakashima, A, Goto, C, Tomiyama, H, Takase, B, Kohro, T, Suzuki, T, Ishizu, T, Ueda, S, Yamazaki, T, Furumoto, T, Kario, K, Inoue, T, Koba, S, Watanabe, K, Takemoto, Y, Hano, T, Sata, M, Ishibashi, Y, Node, K, Maemura, K, Ohya, Y, Furukawa, T, Itoh, H, Ikeda, H, Yamashina, A & Higashi, Y 2018, 'Endothelial dysfunction, increased arterial stiffness, and cardiovascular risk prediction in patients with coronary artery disease: FMD-J (flow-mediated dilation Japan) study A', Journal of the American Heart Association, vol. 7, no. 14, e008588. https://doi.org/10.1161/JAHA.118.008588
Maruhashi, Tatsuya ; Soga, Junko ; Fujimura, Noritaka ; Idei, Naomi ; Mikami, Shinsuke ; Iwamoto, Yumiko ; Iwamoto, Akimichi ; Kajikawa, Masato ; Matsumoto, Takeshi ; Oda, Nozomu ; Kishimoto, Shinji ; Matsui, Shogo ; Hashimoto, Haruki ; Aibara, Yoshiki ; Yusoff, Farina Mohamad ; Hidaka, Takayuki ; Kihara, Yasuki ; Chayama, Kazuaki ; Noma, Kensuke ; Nakashima, Ayumu ; Goto, Chikara ; Tomiyama, Hirofumi ; Takase, Bonpei ; Kohro, Takahide ; Suzuki, Toru ; Ishizu, Tomoko ; Ueda, Shinichiro ; Yamazaki, Tsutomu ; Furumoto, Tomoo ; Kario, Kazuomi ; Inoue, Teruo ; Koba, Shinji ; Watanabe, Kentaro ; Takemoto, Yasuhiko ; Hano, Takuzo ; Sata, Masataka ; Ishibashi, Yutaka ; Node, Koichi ; Maemura, Koji ; Ohya, Yusuke ; Furukawa, Taiji ; Itoh, Hiroshi ; Ikeda, Hisao ; Yamashina, Akira ; Higashi, Yukihito. / Endothelial dysfunction, increased arterial stiffness, and cardiovascular risk prediction in patients with coronary artery disease : FMD-J (flow-mediated dilation Japan) study A. In: Journal of the American Heart Association. 2018 ; Vol. 7, No. 14.
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TY - JOUR

T1 - Endothelial dysfunction, increased arterial stiffness, and cardiovascular risk prediction in patients with coronary artery disease

T2 - FMD-J (flow-mediated dilation Japan) study A

AU - Maruhashi, Tatsuya

AU - Soga, Junko

AU - Fujimura, Noritaka

AU - Idei, Naomi

AU - Mikami, Shinsuke

AU - Iwamoto, Yumiko

AU - Iwamoto, Akimichi

AU - Kajikawa, Masato

AU - Matsumoto, Takeshi

AU - Oda, Nozomu

AU - Kishimoto, Shinji

AU - Matsui, Shogo

AU - Hashimoto, Haruki

AU - Aibara, Yoshiki

AU - Yusoff, Farina Mohamad

AU - Hidaka, Takayuki

AU - Kihara, Yasuki

AU - Chayama, Kazuaki

AU - Noma, Kensuke

AU - Nakashima, Ayumu

AU - Goto, Chikara

AU - Tomiyama, Hirofumi

AU - Takase, Bonpei

AU - Kohro, Takahide

AU - Suzuki, Toru

AU - Ishizu, Tomoko

AU - Ueda, Shinichiro

AU - Yamazaki, Tsutomu

AU - Furumoto, Tomoo

AU - Kario, Kazuomi

AU - Inoue, Teruo

AU - Koba, Shinji

AU - Watanabe, Kentaro

AU - Takemoto, Yasuhiko

AU - Hano, Takuzo

AU - Sata, Masataka

AU - Ishibashi, Yutaka

AU - Node, Koichi

AU - Maemura, Koji

AU - Ohya, Yusuke

AU - Furukawa, Taiji

AU - Itoh, Hiroshi

AU - Ikeda, Hisao

AU - Yamashina, Akira

AU - Higashi, Yukihito

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background—The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. Methods and Results—We measured flow-mediated vasodilation (FMD) and brachial–ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow-up period of 49.2 months, the first primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver-operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio, 0.27; 95% confidence interval, 0.06–0.74; P=0.008) and second (hazard ratio, 0.32; 95% confidence interval, 0.09–0.79; P=0.01) primary outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the first (hazard ratio, 1.86; 95% confidence interval, 1.01–3.44; P=0.04) and second (hazard ratio, 2.19; 95% confidence interval, 1.23–3.90; P=0.008) primary outcomes. Among 4 groups stratified according to the combination of cutoff values of FMD and baPWV, stepwise increases in the calculated risk ratio for the first and second primary outcomes were observed. Conclusions—In patients with coronary artery disease, both FMD and baPWV were significant predictors of cardiovascular events. The combination of FMD and baPWV provided further cardiovascular risk stratification. Clinical Trial Registration—URL: www.umin.ac.jp. Unique identifier: UMIN000012950.

AB - Background—The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. Methods and Results—We measured flow-mediated vasodilation (FMD) and brachial–ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow-up period of 49.2 months, the first primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver-operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio, 0.27; 95% confidence interval, 0.06–0.74; P=0.008) and second (hazard ratio, 0.32; 95% confidence interval, 0.09–0.79; P=0.01) primary outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the first (hazard ratio, 1.86; 95% confidence interval, 1.01–3.44; P=0.04) and second (hazard ratio, 2.19; 95% confidence interval, 1.23–3.90; P=0.008) primary outcomes. Among 4 groups stratified according to the combination of cutoff values of FMD and baPWV, stepwise increases in the calculated risk ratio for the first and second primary outcomes were observed. Conclusions—In patients with coronary artery disease, both FMD and baPWV were significant predictors of cardiovascular events. The combination of FMD and baPWV provided further cardiovascular risk stratification. Clinical Trial Registration—URL: www.umin.ac.jp. Unique identifier: UMIN000012950.

KW - Arterial stiffness

KW - Coronary artery disease

KW - Endothelial function

KW - Flow-induced dilation

KW - Pulse wave velocity

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