Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement

Masaya Iwamuro, Hiroyuki Okada, Yoshiro Kawahara, Katsuji Shinagawa, Toshiaki Morito, Tadashi Yoshino, Kazuhide Yamamoto

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

AIM: To evaluate the endoscopic manifestations and prognoses of gastrointestinal (GI) mantle cell lymphoma (MCL). METHODS: A database search at the Department of Pathology of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences revealed 57 MCL patients with GI involvement. Clinical records were available for 35 of the 57 patients from 21 institutions, and those 35 patients were enrolled in this study. We summarized the gross types of endoscopic features, event-free survival (EFS), and overall survival (OS) of those patients. RESULTS: Of the 35 patients, GI involvement in the esophagus, stomach, and duodenum was found in 2 (5.7%), 26 (74.3%), and 12 (34.3%) patients, respectively. Twenty-one of the 35 patients underwent colonos-copy; among them, GI involvement in the ileum, cecum, colon, and rectum was found in 10 (47.6%), 3 (14.3%), 12 (57.1%), and 10 (47.6%), respectively. Various lesions, such as superfcial, protruded, fold thickening, or ulcerative, were found in the stomach, whereas multiple lymphomatous polyposis (MLP) was dominant from the duodenum to the rectum. Twelve patients were treated with a hyper-CVAD/MA regimen, and they had better OS (3-year rate, 88.3% vs 46.4%, P <0.01) and better EFS (3-year rate, 66.7% vs 33.8%, P <0.05) than the remaining 23 patients who were not treated with this regimen. CONCLUSION: MLP was a representative form of intestinal involvement, whereas a variety of lesions were found in the stomach. The hyper-CVAD/MA regimen may improve survival in these patients.

Original languageEnglish
Pages (from-to)4661-4669
Number of pages9
JournalWorld Journal of Gastroenterology
Volume16
Issue number37
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Mantle-Cell Lymphoma
Stomach
Duodenum
Rectum
Disease-Free Survival
Survival
School Dentistry
Cecum
Ileum
Esophagus
Colon
Medicine
Databases
Pathology

Keywords

  • Chemotherapy
  • Gastrointestinal lymphoma
  • Mantle cell lymphoma
  • Multiple lymphomatous polyposis
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement. / Iwamuro, Masaya; Okada, Hiroyuki; Kawahara, Yoshiro; Shinagawa, Katsuji; Morito, Toshiaki; Yoshino, Tadashi; Yamamoto, Kazuhide.

In: World Journal of Gastroenterology, Vol. 16, No. 37, 10.2010, p. 4661-4669.

Research output: Contribution to journalArticle

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abstract = "AIM: To evaluate the endoscopic manifestations and prognoses of gastrointestinal (GI) mantle cell lymphoma (MCL). METHODS: A database search at the Department of Pathology of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences revealed 57 MCL patients with GI involvement. Clinical records were available for 35 of the 57 patients from 21 institutions, and those 35 patients were enrolled in this study. We summarized the gross types of endoscopic features, event-free survival (EFS), and overall survival (OS) of those patients. RESULTS: Of the 35 patients, GI involvement in the esophagus, stomach, and duodenum was found in 2 (5.7{\%}), 26 (74.3{\%}), and 12 (34.3{\%}) patients, respectively. Twenty-one of the 35 patients underwent colonos-copy; among them, GI involvement in the ileum, cecum, colon, and rectum was found in 10 (47.6{\%}), 3 (14.3{\%}), 12 (57.1{\%}), and 10 (47.6{\%}), respectively. Various lesions, such as superfcial, protruded, fold thickening, or ulcerative, were found in the stomach, whereas multiple lymphomatous polyposis (MLP) was dominant from the duodenum to the rectum. Twelve patients were treated with a hyper-CVAD/MA regimen, and they had better OS (3-year rate, 88.3{\%} vs 46.4{\%}, P <0.01) and better EFS (3-year rate, 66.7{\%} vs 33.8{\%}, P <0.05) than the remaining 23 patients who were not treated with this regimen. CONCLUSION: MLP was a representative form of intestinal involvement, whereas a variety of lesions were found in the stomach. The hyper-CVAD/MA regimen may improve survival in these patients.",
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AU - Morito, Toshiaki

AU - Yoshino, Tadashi

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