Abstract
To evaluate in vivo nitric oxide production in Kawasaki disease (KD), urinary nitrite/nitrate (NOx) excretion was measured in 8 children with KD (age 1.1-2.7 years). Urinary NOx excretion was 0.66 ± 0.22 mmol mmol-1 creatinine (mean ± SD) in the 8 children with KD in the initial stages. The levels were significantly increased compared with those of 12 age-matched healthy control subjects (0.35 ± 0.08 mmol mmol-1 creatinine). Urinary NOx excretion was serially determined in four patients. For each patient, there was a further rise in urinary NOx excretion from baseline levels coincident with the administration of intact-type gammaglobulin and aspirin. With clinical and laboratory improvement, however, urinary NOx excretion declined to the normal range. These findings suggest that endogenous nitric oxide production is enhanced in children with acute KD. Further studies are needed to clarify the role of nitric oxide in the pathogenesis and clinical course of KD.
| Original language | English |
|---|---|
| Pages (from-to) | 43-47 |
| Number of pages | 5 |
| Journal | Scandinavian Journal of Clinical and Laboratory Investigation |
| Volume | 57 |
| Issue number | 1 |
| Publication status | Published - 1997 |
| Externally published | Yes |
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Keywords
- Children
- Cytokines
- Immune activation
- Nitrite oxide synthase
- Urinary nitrite/nitrate
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Endogenous nitric oxide production in Kawasakii disease. / Tsukahara, Hirokazu; Kikuchi, K.; Matsuda, M.; Saito, M.; Hata, I.; Tsuchida, S.; Sudo, M.
In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 57, No. 1, 1997, p. 43-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous nitric oxide production in Kawasakii disease
AU - Tsukahara, Hirokazu
AU - Kikuchi, K.
AU - Matsuda, M.
AU - Saito, M.
AU - Hata, I.
AU - Tsuchida, S.
AU - Sudo, M.
PY - 1997
Y1 - 1997
N2 - To evaluate in vivo nitric oxide production in Kawasaki disease (KD), urinary nitrite/nitrate (NOx) excretion was measured in 8 children with KD (age 1.1-2.7 years). Urinary NOx excretion was 0.66 ± 0.22 mmol mmol-1 creatinine (mean ± SD) in the 8 children with KD in the initial stages. The levels were significantly increased compared with those of 12 age-matched healthy control subjects (0.35 ± 0.08 mmol mmol-1 creatinine). Urinary NOx excretion was serially determined in four patients. For each patient, there was a further rise in urinary NOx excretion from baseline levels coincident with the administration of intact-type gammaglobulin and aspirin. With clinical and laboratory improvement, however, urinary NOx excretion declined to the normal range. These findings suggest that endogenous nitric oxide production is enhanced in children with acute KD. Further studies are needed to clarify the role of nitric oxide in the pathogenesis and clinical course of KD.
AB - To evaluate in vivo nitric oxide production in Kawasaki disease (KD), urinary nitrite/nitrate (NOx) excretion was measured in 8 children with KD (age 1.1-2.7 years). Urinary NOx excretion was 0.66 ± 0.22 mmol mmol-1 creatinine (mean ± SD) in the 8 children with KD in the initial stages. The levels were significantly increased compared with those of 12 age-matched healthy control subjects (0.35 ± 0.08 mmol mmol-1 creatinine). Urinary NOx excretion was serially determined in four patients. For each patient, there was a further rise in urinary NOx excretion from baseline levels coincident with the administration of intact-type gammaglobulin and aspirin. With clinical and laboratory improvement, however, urinary NOx excretion declined to the normal range. These findings suggest that endogenous nitric oxide production is enhanced in children with acute KD. Further studies are needed to clarify the role of nitric oxide in the pathogenesis and clinical course of KD.
KW - Children
KW - Cytokines
KW - Immune activation
KW - Nitrite oxide synthase
KW - Urinary nitrite/nitrate
UR - http://www.scopus.com/inward/record.url?scp=0030996643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030996643&partnerID=8YFLogxK
M3 - Article
C2 - 9127456
AN - SCOPUS:0030996643
VL - 57
SP - 43
EP - 47
JO - Scandinavian Journal of Clinical and Laboratory Investigation
JF - Scandinavian Journal of Clinical and Laboratory Investigation
SN - 0036-5513
IS - 1
ER -