Endogenous Interleukin 18 Suppresses Hyperglycemia and Hyperinsulinemia during the Acute Phase of Endotoxemia in Mice

Hayato Yamashita, Michiko Aoyama-Ishikawa, Miki Takahara, Chisato Yamauchi, Taketo Inoue, Makoto Miyoshi, Noriaki Maeshige, Makoto Usami, Atsunori Nakao, Joji Kotani

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2 Citations (Scopus)

Abstract

Background: Hyperglycemia associated with insulin resistance is common among critically ill patients. Interleukin (IL)-18 has been linked with hyperglycemia and insulin resistance in chronic disease, but the relation between IL-18 and insulin resistance during critical illness was unexplored. This study investigated whether IL-18 modulates hyperglycemia and insulin resistance during acute inflammation. Methods: We injected lipopolysaccharide (LPS) 40 mg/kg into wild-type (WT) and IL-18 knockout (KO) mice to induce endotoxemia and examined insulin resistance and insulin-dependent signaling pathways during the acute phase. Results: During the first hour after LPS treatment, IL-18 KO mice showed higher blood glucose and insulin and less insulin receptor substrate-1 and less phosphorylated Akt in the liver compared with WT mice. Interleukin-18 KO mice exhibited better survival after LPS treatment. Conclusions: The findings suggest that endogenous IL-18 may attenuate hyperglycemia and modulate insulin signaling in liver. Accordingly, IL-18 may modulate glucose tolerance during acute inflammation.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalSurgical Infections
Volume16
Issue number1
DOIs
Publication statusPublished - Feb 1 2015

ASJC Scopus subject areas

  • Surgery
  • Microbiology (medical)
  • Infectious Diseases

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    Yamashita, H., Aoyama-Ishikawa, M., Takahara, M., Yamauchi, C., Inoue, T., Miyoshi, M., Maeshige, N., Usami, M., Nakao, A., & Kotani, J. (2015). Endogenous Interleukin 18 Suppresses Hyperglycemia and Hyperinsulinemia during the Acute Phase of Endotoxemia in Mice. Surgical Infections, 16(1), 90-96. https://doi.org/10.1089/sur.2013.269