We measured neopterin (NPT), an indirect marker of gamma (γ)-interferon, and the activity of thymidine phosphorylase (dThdPase) in the advancing front of colorectal carcinoma and in normal mucosa. Cancer showed a higher concentration of NPT than normal mucosa and also showed significantly higher (p < 0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that endogenous γ-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availability of thymidine.
|Number of pages||8|
|Journal||Research Communications in Molecular Pathology and Pharmacology|
|Publication status||Published - Jan 1 1995|
ASJC Scopus subject areas
- Molecular Medicine