Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue

H. Iwagaki, A. Hizuta, K. Mori, Tadashi Yoshino, K. Kawahara, N. Tanaka, K. Orita

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We measured neopterin (NPT), an indirect marker of gamma (γ)-interferon, and the activity of thymidine phosphorylase (dThdPase) in the advancing front of colorectal carcinoma and in normal mucosa. Cancer showed a higher concentration of NPT than normal mucosa and also showed significantly higher (p <0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that endogenous γ-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availability of thymidine.

Original languageEnglish
Pages (from-to)345-352
Number of pages8
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume87
Issue number3
Publication statusPublished - 1995

Fingerprint

Thymidine Phosphorylase
Neopterin
Interferon-gamma
Colorectal Neoplasms
Mucous Membrane
Thymidine
Nucleic Acids
Interferons
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue. / Iwagaki, H.; Hizuta, A.; Mori, K.; Yoshino, Tadashi; Kawahara, K.; Tanaka, N.; Orita, K.

In: Research Communications in Molecular Pathology and Pharmacology, Vol. 87, No. 3, 1995, p. 345-352.

Research output: Contribution to journalArticle

Iwagaki, H. ; Hizuta, A. ; Mori, K. ; Yoshino, Tadashi ; Kawahara, K. ; Tanaka, N. ; Orita, K. / Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue. In: Research Communications in Molecular Pathology and Pharmacology. 1995 ; Vol. 87, No. 3. pp. 345-352.
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AU - Tanaka, N.

AU - Orita, K.

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