Endogenous gamma-interferon activates thymidine phosphorylase in colorectal cancer tissue

H. Iwagaki, A. Hizuta, K. Mori, T. Yoshino, K. Kawahara, N. Tanaka, K. Orita

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We measured neopterin (NPT), an indirect marker of gamma (γ)-interferon, and the activity of thymidine phosphorylase (dThdPase) in the advancing front of colorectal carcinoma and in normal mucosa. Cancer showed a higher concentration of NPT than normal mucosa and also showed significantly higher (p < 0.0001) dThdPase activity than normal mucosa. There was a strong correlation between NPT concentration and dThdPase activity in cancerous and normal mucosa. These results suggest that endogenous γ-interferon could activate dThdPase activity, which is essential to nucleic acid metabolism because it regulates the availability of thymidine.

Original languageEnglish
Pages (from-to)345-352
Number of pages8
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume87
Issue number3
Publication statusPublished - Jan 1 1995

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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