Encapsulated cell grafting into the brain for the treatment of neurological disorders

Isao Date, Takashi Ohmoto

Research output: Contribution to journalArticle

Abstract

The merits of using cell lines as donors for neural grafting are that they are unlimited as donor source theoretically and they can be genetically modified. However, when using cell lines as donors, immunological rejection and tumor formation should be controlled. To overcome these issues, encapsulated cell grafting technique using semipermeable membrane consisted of polymer has been developed. This technique also has safety because the capsule is retrieval after transplantation. In this review, encapsulated cell grafting research using neurotransmitter and/or neurotrophic factor secreting cell lines will be summarized and future perspectives will be performed from the aspects of therapy for neurological disorders.

Original languageEnglish
Pages (from-to)326-332
Number of pages7
JournalJapanese Journal of Neurosurgery
Volume11
Issue number5
Publication statusPublished - 2002

Fingerprint

Nervous System Diseases
Cell Line
Brain
Nerve Growth Factors
Capsules
Neurotransmitter Agents
Polymers
Transplantation
Safety
Membranes
Research
Neoplasms
Therapeutics

Keywords

  • Cell line
  • Encapsulated cells
  • Neural transplantation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Encapsulated cell grafting into the brain for the treatment of neurological disorders. / Date, Isao; Ohmoto, Takashi.

In: Japanese Journal of Neurosurgery, Vol. 11, No. 5, 2002, p. 326-332.

Research output: Contribution to journalArticle

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