Enantioselective synthesis of anti homoallylic alcohols from terminal alkynes and aldehydes based on concomitant use of a cationic iridium complex and a chiral phosphoric acid

Tomoya Miura, Yui Nishida, Masao Morimoto, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

We report a highly diastereo- and enantioselective synthesis of anti homoallylic alcohols from terminal alkynes via (E)-1-alkenylboronates based upon two catalytic reactions: a cationic iridium complex-catalyzed olefin transposition of (E)-1-alkenylboronates and a chiral phosphoric acid-catalyzed allylation reaction of aldehydes.

Original languageEnglish
Pages (from-to)11497-11500
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number31
DOIs
Publication statusPublished - Aug 7 2013
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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