Enantioselective synthesis of 3,4-dihydroisoquinolin-1(2H)-ones by nickel-catalyzed denitrogenative annulation of 1,2,3-benzotriazin-4(3H)-ones with allenes

Motoshi Yamauchi, Masao Morimoto, Tomoya Miura, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)

Abstract

(Chemical Equation Presented) A denitrogenative annulation reaction of 1,2,3-benzotriazin-4(3H)-ones with allenes catalyzed by a nickel-phosphine complex to produce a variety of substituted 3,4-dihydroisoquinolin-1(2H)-ones in a regioselective manner is described. A highly enantioselective version, as well as structural evidence for the mechanistic course of this reaction, is also presented.

Original languageEnglish
Pages (from-to)54-55
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number1
DOIs
Publication statusPublished - Jan 13 2010
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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