Abstract
We developed an enantioselective desymmetrization of 1,3-diols by a chiral N,N-dimethyl-4-aminopyridine (DMAP) derivative containing a 1,1-binaphthyl with tert-alcohol units. The reactions required only 0.1 mol% of catalyst and showed moderate to high chemoselectivity (monoacylation vs. diacylation) and enantioselectivity (14 examples, up to 95:5 er). Several control experiments revealed that diol units in both the substrate and the catalyst are important to achieve high enantioselectivity.
Original language | English |
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Pages (from-to) | 1360-1363 |
Number of pages | 4 |
Journal | Chemistry Letters |
Volume | 47 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- 1 3-Diol
- Chiral DMAP derivative
- Desymmetrization
ASJC Scopus subject areas
- Chemistry(all)