Enantioselective cyanoethoxycarbonylation of isatins promoted by a Lewis base-Brønsted acid cooperative catalyst

Yoshihiro Ogura, Matsujiro Akakura, Akira Sakakura, Kazuaki Ishihara

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Teaming up to make it happen: In the title reaction, the Lewis basic site of the catalyst activated ethyl cyanoformate, and the deep and flexible Brønsted acidic cavity stabilized and selectively recognized the key reaction intermediate to promote asymmetric acylation (see scheme).

Original languageEnglish
Pages (from-to)8299-8303
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number32
DOIs
Publication statusPublished - Aug 5 2013

Keywords

  • Brønsted acids
  • Lewis bases
  • asymmetric catalysis
  • isatins
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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