Enantiomerically pure 1,2-bis(isopropylmethylphosphino)benzene and its use in highly enantioselective Rh-catalyzed asymmetric hydrogenation

Tomoya Miura, Tsuneo Imamoto

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

A new P-chiral phosphine ligand with a 1,2-phenylene unit, (S,S)-1,2- bis(isoprophylmethylphosphino)benzene, has been synthesized from 1,2- bis(methylphosphino)benzene. Its rhodium complex is highly effective in asymmetric hydrogenation of dehydroamino acid methyl esters to provide enatioselectivities of up to 98%.

Original languageEnglish
Pages (from-to)4833-4836
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number26
DOIs
Publication statusPublished - Jun 25 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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