Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production: Potent TNF-α production inhibitors

Hiroyuki Miyachi; Akihiko Azuma; Erika Hioki; Shigeo Iwasaki; Yuichi Hashimoto

doi:10.1016/0960-894X(96)00409-X

Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production: Potent TNF-α production inhibitors

Hiroyuki Miyachi, Akihiko Azuma, Erika Hioki, Shigeo Iwasaki, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In optically active phthalimide analogs of thalidomide, the inducer-specific TNF-α production-enhancing and -inhibiting activities are separated. This implies that the target molecules of the two activities are different.

Original language	English
Pages (from-to)	2293-2298
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	19
DOIs	https://doi.org/10.1016/0960-894X(96)00409-X
Publication status	Published - Oct 8 1996

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(96)00409-X

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title = "Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production: Potent TNF-α production inhibitors",

abstract = "In optically active phthalimide analogs of thalidomide, the inducer-specific TNF-α production-enhancing and -inhibiting activities are separated. This implies that the target molecules of the two activities are different.",

author = "Hiroyuki Miyachi and Akihiko Azuma and Erika Hioki and Shigeo Iwasaki and Yuichi Hashimoto",

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AU - Miyachi, Hiroyuki

AU - Azuma, Akihiko

AU - Hioki, Erika

AU - Iwasaki, Shigeo

AU - Hashimoto, Yuichi

PY - 1996/10/8

Y1 - 1996/10/8

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AB - In optically active phthalimide analogs of thalidomide, the inducer-specific TNF-α production-enhancing and -inhibiting activities are separated. This implies that the target molecules of the two activities are different.

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Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production: Potent TNF-α production inhibitors

Abstract

ASJC Scopus subject areas

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