Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production: Potent TNF-α production inhibitors

Hiroyuki Miyachi, Akihiko Azuma, Erika Hioki, Shigeo Iwasaki, Yuichi Hashimoto

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In optically active phthalimide analogs of thalidomide, the inducer-specific TNF-α production-enhancing and -inhibiting activities are separated. This implies that the target molecules of the two activities are different.

Original languageEnglish
Pages (from-to)2293-2298
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number19
DOIs
Publication statusPublished - Oct 8 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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