Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production

Potent TNF-α production inhibitors

Hiroyuki Miyachi, Akihiko Azuma, Erika Hioki, Shigeo Iwasaki, Yuichi Hashimoto

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In optically active phthalimide analogs of thalidomide, the inducer-specific TNF-α production-enhancing and -inhibiting activities are separated. This implies that the target molecules of the two activities are different.

Original languageEnglish
Pages (from-to)2293-2298
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number19
DOIs
Publication statusPublished - Oct 8 1996
Externally publishedYes

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Thalidomide
Tumor Necrosis Factor-alpha
Molecules
phthalimide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production : Potent TNF-α production inhibitors. / Miyachi, Hiroyuki; Azuma, Akihiko; Hioki, Erika; Iwasaki, Shigeo; Hashimoto, Yuichi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 19, 08.10.1996, p. 2293-2298.

Research output: Contribution to journalArticle

Miyachi, Hiroyuki ; Azuma, Akihiko ; Hioki, Erika ; Iwasaki, Shigeo ; Hashimoto, Yuichi. / Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production : Potent TNF-α production inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 19. pp. 2293-2298.
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