Abstract
In optically active phthalimide analogs of thalidomide, the inducer-specific TNF-α production-enhancing and -inhibiting activities are separated. This implies that the target molecules of the two activities are different.
| Original language | English |
|---|---|
| Pages (from-to) | 2293-2298 |
| Number of pages | 6 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 6 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - Oct 8 1996 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Miyachi, H., Azuma, A., Hioki, E., Iwasaki, S., & Hashimoto, Y. (1996). Enantio-dependence of inducer-specific bidirectional regulation of tumor necrosis factor (TNF)-alpha production: Potent TNF-α production inhibitors. Bioorganic and Medicinal Chemistry Letters, 6(19), 2293-2298. https://doi.org/10.1016/0960-894X(96)00409-X