Emergence of daptomycin-resistant Staphylococcus aureus during treatment

Hideharu Hagiya, Yuto Haruki, Taeko Uchida, Tomoko Wada, Sumiko Shiota, Tomoharu Ishida, Hiroko Ogawa, Tomoko Murase, Fumio Otsuka

Research output: Contribution to journalArticle

Abstract

A 68-year-old man with persistent bacteremia accompanying a large iliopsoas abscess, vertebral osteomyelitis, discitis and central venous port infection caused by methicillin-resistant Staphylococcus aureus (MRSA) was admitted to our hospital. During the course of treatment, the emergence of a daptomycin (DAP)-resistant MRSA strain was confirmed; the minimum inhibitory concentration was 1 to 2 μg/mL for vancomycin and more than 1 μg/mL for DAP. Although the bacterial cell wall was not significantly thickened, an increased positive surface charge and single-nucleotide polymorphism within mprF have been confirmed in DAPresistant strains. Still rare, but clinicians need to be cautious of the emergence of DAP-resistant MRSA during treatment.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalInternal Medicine
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Daptomycin
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Psoas Abscess
Discitis
Microbial Sensitivity Tests
Osteomyelitis
Vancomycin
Bacteremia
Cell Wall
Single Nucleotide Polymorphism
Therapeutics
Infection

Keywords

  • Bacterial surface charge
  • Cell wall thickness
  • Creeping
  • MprF
  • Single-nucleotide polymorphism (SNP)
  • Staphylococcus aureus bacteremia (SAB)

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Emergence of daptomycin-resistant Staphylococcus aureus during treatment. / Hagiya, Hideharu; Haruki, Yuto; Uchida, Taeko; Wada, Tomoko; Shiota, Sumiko; Ishida, Tomoharu; Ogawa, Hiroko; Murase, Tomoko; Otsuka, Fumio.

In: Internal Medicine, Vol. 55, No. 1, 01.01.2016, p. 73-78.

Research output: Contribution to journalArticle

Hagiya, H, Haruki, Y, Uchida, T, Wada, T, Shiota, S, Ishida, T, Ogawa, H, Murase, T & Otsuka, F 2016, 'Emergence of daptomycin-resistant Staphylococcus aureus during treatment', Internal Medicine, vol. 55, no. 1, pp. 73-78. https://doi.org/10.2169/internalmedicine.55.4763
Hagiya H, Haruki Y, Uchida T, Wada T, Shiota S, Ishida T et al. Emergence of daptomycin-resistant Staphylococcus aureus during treatment. Internal Medicine. 2016 Jan 1;55(1):73-78. https://doi.org/10.2169/internalmedicine.55.4763
Hagiya, Hideharu ; Haruki, Yuto ; Uchida, Taeko ; Wada, Tomoko ; Shiota, Sumiko ; Ishida, Tomoharu ; Ogawa, Hiroko ; Murase, Tomoko ; Otsuka, Fumio. / Emergence of daptomycin-resistant Staphylococcus aureus during treatment. In: Internal Medicine. 2016 ; Vol. 55, No. 1. pp. 73-78.
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