Emergence of daptomycin-resistant Staphylococcus aureus during treatment

Hideharu Hagiya, Yuto Haruki, Taeko Uchida, Tomoko Wada, Sumiko Shiota, Tomoharu Ishida, Hiroko Ogawa, Tomoko Murase, Fumio Otsuka

Research output: Contribution to journalArticle

Abstract

A 68-year-old man with persistent bacteremia accompanying a large iliopsoas abscess, vertebral osteomyelitis, discitis and central venous port infection caused by methicillin-resistant Staphylococcus aureus (MRSA) was admitted to our hospital. During the course of treatment, the emergence of a daptomycin (DAP)-resistant MRSA strain was confirmed; the minimum inhibitory concentration was 1 to 2 μg/mL for vancomycin and more than 1 μg/mL for DAP. Although the bacterial cell wall was not significantly thickened, an increased positive surface charge and single-nucleotide polymorphism within mprF have been confirmed in DAPresistant strains. Still rare, but clinicians need to be cautious of the emergence of DAP-resistant MRSA during treatment.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalInternal Medicine
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Keywords

  • Bacterial surface charge
  • Cell wall thickness
  • Creeping
  • MprF
  • Single-nucleotide polymorphism (SNP)
  • Staphylococcus aureus bacteremia (SAB)

ASJC Scopus subject areas

  • Internal Medicine

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