Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma

Tomoko Miyata-Takata, Katsuyoshi Takata, Tomohiro Toji, Naoe Goto, Senji Kasahara, Takeshi Takahashi, Akira Tari, Mai Noujima-Harada, Takafumi Miyata, Yasuharu Sato, Tadashi Yoshino

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Abstract

Proinflammatory cytokines that are produced by helper T cells (Th) regulate immune reactions, facilitate class switching of B cells, and prolong the lifespan of B and T cells. Eradication therapy using antibiotics is sometimes effective against gastrointestinal (GI) malignant lymphoma, suggesting that the tumor development or progression is affected by the inflammatory microenvironment. In the present study, serum samples from 148 patients with various subtypes of malignant lymphoma were tested for 11 proinflammatory Th1/Th2 cytokines. In the comparison by subtype or GI lesions, serum interleukin (IL)-8 (P=6.7E-05), IL-4 (P=7.5E-05), and IL-1β (P=0.0043) levels showed significant differences among subtypes, being particularly elevated in follicular lymphomas (FL) and mucosa-associated lymphoid tissue (MALT) lymphomas. Serum IL-8 levels were elevated in GI-FL and MALT lymphomas, and serum IL-4 and IL-1 β levels were elevated in MALT lymphomas. These findings show that GI low-grade B-cell lymphoma could develop against the background of an inflammatory microenvironment. Thus, these cytokines may be useful as diagnostic markers and could provide new insights into tumor development.

Original languageEnglish
Article number18434
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Dec 17 2015

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Marginal Zone B-Cell Lymphoma
B-Cell Lymphoma
Interleukin-8
Interleukin-1
Interleukin-4
Non-Hodgkin's Lymphoma
Serum
Follicular Lymphoma
Cytokines
Lymphoma
B-Lymphocytes
Immunoglobulin Class Switching
Helper-Inducer T-Lymphocytes
Neoplasms
Anti-Bacterial Agents
T-Lymphocytes

ASJC Scopus subject areas

  • General

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Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma. / Miyata-Takata, Tomoko; Takata, Katsuyoshi; Toji, Tomohiro; Goto, Naoe; Kasahara, Senji; Takahashi, Takeshi; Tari, Akira; Noujima-Harada, Mai; Miyata, Takafumi; Sato, Yasuharu; Yoshino, Tadashi.

In: Scientific Reports, Vol. 5, 18434, 17.12.2015.

Research output: Contribution to journalArticle

Miyata-Takata, T, Takata, K, Toji, T, Goto, N, Kasahara, S, Takahashi, T, Tari, A, Noujima-Harada, M, Miyata, T, Sato, Y & Yoshino, T 2015, 'Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma', Scientific Reports, vol. 5, 18434. https://doi.org/10.1038/srep18434
Miyata-Takata, Tomoko ; Takata, Katsuyoshi ; Toji, Tomohiro ; Goto, Naoe ; Kasahara, Senji ; Takahashi, Takeshi ; Tari, Akira ; Noujima-Harada, Mai ; Miyata, Takafumi ; Sato, Yasuharu ; Yoshino, Tadashi. / Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma. In: Scientific Reports. 2015 ; Vol. 5.
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