TY - JOUR
T1 - Elevation of serum hepatocyte growth factor during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization
AU - Fujii, Keiko
AU - Ishimaru, Fumihiko
AU - Kozuka, Teruhiko
AU - Matsuo, Keitaro
AU - Nakase, Koichi
AU - Kataoka, Itaru
AU - Tabayashi, Takayuki
AU - Shinagawa, Katsuji
AU - Ikeda, Kazuma
AU - Harada, Mine
AU - Tanimoto, Mitsune
PY - 2004/1
Y1 - 2004/1
N2 - We examined serum levels of the angiogenic factors, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF), in normal donors for allogeneic peripheral blood stem cell (PBSC) transplantation. Granulocyte colony-stimulating factor (G-CSF) (filgrastim 400 μg/m2/d) was administered to 23 donors for 5 d and aphereses were performed on days 4 and 5. Although bFGF remained at similar levels after G-CSF treatment, serum VEGF and HGF levels increased 1.5-fold (n = 13; P = 0.02) and 6.8-fold (n = 23; P < 0.0001) respectively. The serum HGF level before G-CSF administration on day 1 correlated inversely with mobilized CD34+ cell numbers. Time course kinetics of HGF showed that on the day after G-CSF administration (day 2), serum HGF levels increased to 3678 pg/ml. For auto PBSC mobilization with chemotherapy and G-CSF 200 μg/m 2/d (n = 8), we observed similar HGF elevation, which appeared to be dose-dependent on the G-CSF administered.
AB - We examined serum levels of the angiogenic factors, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF), in normal donors for allogeneic peripheral blood stem cell (PBSC) transplantation. Granulocyte colony-stimulating factor (G-CSF) (filgrastim 400 μg/m2/d) was administered to 23 donors for 5 d and aphereses were performed on days 4 and 5. Although bFGF remained at similar levels after G-CSF treatment, serum VEGF and HGF levels increased 1.5-fold (n = 13; P = 0.02) and 6.8-fold (n = 23; P < 0.0001) respectively. The serum HGF level before G-CSF administration on day 1 correlated inversely with mobilized CD34+ cell numbers. Time course kinetics of HGF showed that on the day after G-CSF administration (day 2), serum HGF levels increased to 3678 pg/ml. For auto PBSC mobilization with chemotherapy and G-CSF 200 μg/m 2/d (n = 8), we observed similar HGF elevation, which appeared to be dose-dependent on the G-CSF administered.
KW - Granulocyte-colony stimulating factor
KW - Hepatocyte growth factor
KW - Peripheral blood stem cell mobilization
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U2 - 10.1046/j.1365-2141.2003.04745.x
DO - 10.1046/j.1365-2141.2003.04745.x
M3 - Article
C2 - 14687029
AN - SCOPUS:9144224181
VL - 124
SP - 190
EP - 194
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 2
ER -