Elevation of serum hepatocyte growth factor during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization

Keiko Fujii, Fumihiko Ishimaru, Teruhiko Kozuka, Keitaro Matsuo, Koichi Nakase, Itaru Kataoka, Takayuki Tabayashi, Katsuji Shinagawa, Kazuma Ikeda, Mine Harada, Mitsune Tanimoto

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44 Citations (Scopus)

Abstract

We examined serum levels of the angiogenic factors, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF), in normal donors for allogeneic peripheral blood stem cell (PBSC) transplantation. Granulocyte colony-stimulating factor (G-CSF) (filgrastim 400 μg/m2/d) was administered to 23 donors for 5 d and aphereses were performed on days 4 and 5. Although bFGF remained at similar levels after G-CSF treatment, serum VEGF and HGF levels increased 1.5-fold (n = 13; P = 0.02) and 6.8-fold (n = 23; P < 0.0001) respectively. The serum HGF level before G-CSF administration on day 1 correlated inversely with mobilized CD34+ cell numbers. Time course kinetics of HGF showed that on the day after G-CSF administration (day 2), serum HGF levels increased to 3678 pg/ml. For auto PBSC mobilization with chemotherapy and G-CSF 200 μg/m 2/d (n = 8), we observed similar HGF elevation, which appeared to be dose-dependent on the G-CSF administered.

Original languageEnglish
Pages (from-to)190-194
Number of pages5
JournalBritish Journal of Haematology
Volume124
Issue number2
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Granulocyte-colony stimulating factor
  • Hepatocyte growth factor
  • Peripheral blood stem cell mobilization

ASJC Scopus subject areas

  • Hematology

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    Fujii, K., Ishimaru, F., Kozuka, T., Matsuo, K., Nakase, K., Kataoka, I., Tabayashi, T., Shinagawa, K., Ikeda, K., Harada, M., & Tanimoto, M. (2004). Elevation of serum hepatocyte growth factor during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization. British Journal of Haematology, 124(2), 190-194. https://doi.org/10.1046/j.1365-2141.2003.04745.x