Elevation of plasma interleukin-6 level in patients undergoing oral and maxillofacial surgery

Takuya Miyawaki, Shigeru Maeda, Masahiko Shimada

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective. The purpose of this study was to evaluate the response of peripheral interleukin-6 associated with oral and maxillofacial surgery. Study design. Fifteen patients undergoing elective oral and maxillofacial surgery were studied. We investigated the change in plasma interleukin-6 level during and after surgery and the correlation between plasma interleukin-6 level and surgical procedure. Plasma interleukin-6 levels were measured by enzyme-linked immunosorbent assay. Statistical significance was determined by nonparametric methods. Results. Elevation of plasma interleukin-6 level was detected at 2 to 6 hours after incision and observed to reach a peak level within 6 hours after the end of surgery. There were significant correlations between plasma interleukin-6 level and duration of surgery or response of C-reactive protein. Conclusion. The results suggested that interleukin-6 would be released by surgical injury and elevation of plasma interleukin-6 level would be associated with magnitude of tissue damage in oral and maxillofacial surgery.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalOral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Volume81
Issue number1
DOIs
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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