Elevation of plasma interleukin-6 level in patients undergoing oral and maxillofacial surgery

Takuya Miyawaki, Shigeru Maeda, Masahiko Shimada

Research output: Contribution to journalArticle

10 Citations (Scopus)


Objective. The purpose of this study was to evaluate the response of peripheral interleukin-6 associated with oral and maxillofacial surgery. Study design. Fifteen patients undergoing elective oral and maxillofacial surgery were studied. We investigated the change in plasma interleukin-6 level during and after surgery and the correlation between plasma interleukin-6 level and surgical procedure. Plasma interleukin-6 levels were measured by enzyme-linked immunosorbent assay. Statistical significance was determined by nonparametric methods. Results. Elevation of plasma interleukin-6 level was detected at 2 to 6 hours after incision and observed to reach a peak level within 6 hours after the end of surgery. There were significant correlations between plasma interleukin-6 level and duration of surgery or response of C-reactive protein. Conclusion. The results suggested that interleukin-6 would be released by surgical injury and elevation of plasma interleukin-6 level would be associated with magnitude of tissue damage in oral and maxillofacial surgery.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Issue number1
Publication statusPublished - 1996


ASJC Scopus subject areas

  • Dentistry(all)
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

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