Objective. The purpose of this study was to evaluate the response of peripheral interleukin-6 associated with oral and maxillofacial surgery. Study design. Fifteen patients undergoing elective oral and maxillofacial surgery were studied. We investigated the change in plasma interleukin-6 level during and after surgery and the correlation between plasma interleukin-6 level and surgical procedure. Plasma interleukin-6 levels were measured by enzyme-linked immunosorbent assay. Statistical significance was determined by nonparametric methods. Results. Elevation of plasma interleukin-6 level was detected at 2 to 6 hours after incision and observed to reach a peak level within 6 hours after the end of surgery. There were significant correlations between plasma interleukin-6 level and duration of surgery or response of C-reactive protein. Conclusion. The results suggested that interleukin-6 would be released by surgical injury and elevation of plasma interleukin-6 level would be associated with magnitude of tissue damage in oral and maxillofacial surgery.
|Number of pages||6|
|Journal||Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics|
|Publication status||Published - 1996|
ASJC Scopus subject areas
- Oral Surgery