Elevated tyrosine hydroxylase nRNA levels in medulla oblongata of spontaneously hypertensive rats

Toshio Kumai; Masami Tanaka; Minoru Watanabe; Hironori Nakura; Tomonori Tateishi; Shinichi Kobayashi

doi:10.1016/0169-328X(95)00296-5

Elevated tyrosine hydroxylase nRNA levels in medulla oblongata of spontaneously hypertensive rats

Toshio Kumai, Masami Tanaka, Minoru Watanabe, Hironori Nakura, Tomonori Tateishi, Shinichi Kobayashi

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The present study has investigated the expression of tyrosine hydroxylase (TH) mRNA and its activity in medulla oblongata of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The TH mRNA levels were determined by Northern blot and dot blot analyses. The TH activity and the expression of TH mRNA in medulla oblongata of SHR were significantly higher than those of WKY. These results suggest that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA which increases norepinephrine levels in the medulla oblongata.

Original language	English
Pages (from-to)	197-199
Number of pages	3
Journal	Molecular Brain Research
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0169-328X(95)00296-5
Publication status	Published - Feb 1996
Externally published	Yes

Keywords

Medulla oblongata
Spontaneously hypertensive rats
Tyrosine hydroxylase mRNA

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(95)00296-5

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abstract = "The present study has investigated the expression of tyrosine hydroxylase (TH) mRNA and its activity in medulla oblongata of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The TH mRNA levels were determined by Northern blot and dot blot analyses. The TH activity and the expression of TH mRNA in medulla oblongata of SHR were significantly higher than those of WKY. These results suggest that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA which increases norepinephrine levels in the medulla oblongata.",

keywords = "Medulla oblongata, Spontaneously hypertensive rats, Tyrosine hydroxylase mRNA",

author = "Toshio Kumai and Masami Tanaka and Minoru Watanabe and Hironori Nakura and Tomonori Tateishi and Shinichi Kobayashi",

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T1 - Elevated tyrosine hydroxylase nRNA levels in medulla oblongata of spontaneously hypertensive rats

AU - Kumai, Toshio

AU - Tanaka, Masami

AU - Watanabe, Minoru

AU - Nakura, Hironori

AU - Tateishi, Tomonori

AU - Kobayashi, Shinichi

PY - 1996/2

Y1 - 1996/2

N2 - The present study has investigated the expression of tyrosine hydroxylase (TH) mRNA and its activity in medulla oblongata of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The TH mRNA levels were determined by Northern blot and dot blot analyses. The TH activity and the expression of TH mRNA in medulla oblongata of SHR were significantly higher than those of WKY. These results suggest that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA which increases norepinephrine levels in the medulla oblongata.

AB - The present study has investigated the expression of tyrosine hydroxylase (TH) mRNA and its activity in medulla oblongata of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The TH mRNA levels were determined by Northern blot and dot blot analyses. The TH activity and the expression of TH mRNA in medulla oblongata of SHR were significantly higher than those of WKY. These results suggest that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA which increases norepinephrine levels in the medulla oblongata.

KW - Medulla oblongata

KW - Spontaneously hypertensive rats

KW - Tyrosine hydroxylase mRNA

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Elevated tyrosine hydroxylase nRNA levels in medulla oblongata of spontaneously hypertensive rats

Abstract

Keywords

ASJC Scopus subject areas

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