Abstract
Objectives: Establish a correlation between serum soluble interleukin 2 receptor (sIL-2R) levels and clinical characteristics of follicular lymphoma patients with gastrointestinal involvement. Design and methods: Patients (n = 44) presenting with follicular lymphoma lesions in the gastrointestinal tract were enrolled into the study and divided into 2 groups based on sIL-2R levels (normal vs. elevated). Clinical characteristics were also analyzed between groups. Results: Patients with elevated sIL-2R levels likely had systemic follicular lymphoma involvement (Ann Arbor system staging IIIES/IV or Lugano system staging II-2/IV), involvement of 5 or more nodal areas, and presentation of bulky tumors in the gastrointestinal tract. These patients also presented a high Follicular Lymphoma International Prognostic Index (FLIPI) score, suggestive of poor prognosis. No differences were found among other clinical characteristics including sex, age at lymphoma diagnosis, histological grade, LDH levels, bone marrow involvement, hemoglobin levels, and identification of tracer accumulation in gastrointestinal lesions by positron-emission tomography scanning. Conclusions: sIL-2R levels can be used as an independent prognostic index in follicular lymphoma patients based on the correlation with the FLIPI score. Moreover, since high sIL-2R levels were associated with a large tumor bulk, sIL-2R may serve as a good indicator for monitoring disease relapse or progression.
| Original language | English |
|---|---|
| Pages (from-to) | 191-195 |
| Number of pages | 5 |
| Journal | Clinical Biochemistry |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 2014 |
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Keywords
- Gastrointestinal lymphoma
- Primary intestinal follicular lymphoma
- Soluble interleukin 2 receptor
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement. / Iwamuro, Masaya; Shinagawa, Katsuji; Okada, Hiroyuki; Takata, Katsuyoshi; Yoshino, Tadashi; Yamamoto, Kazuhide.
In: Clinical Biochemistry, Vol. 47, No. 3, 02.2014, p. 191-195.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement
AU - Iwamuro, Masaya
AU - Shinagawa, Katsuji
AU - Okada, Hiroyuki
AU - Takata, Katsuyoshi
AU - Yoshino, Tadashi
AU - Yamamoto, Kazuhide
PY - 2014/2
Y1 - 2014/2
N2 - Objectives: Establish a correlation between serum soluble interleukin 2 receptor (sIL-2R) levels and clinical characteristics of follicular lymphoma patients with gastrointestinal involvement. Design and methods: Patients (n = 44) presenting with follicular lymphoma lesions in the gastrointestinal tract were enrolled into the study and divided into 2 groups based on sIL-2R levels (normal vs. elevated). Clinical characteristics were also analyzed between groups. Results: Patients with elevated sIL-2R levels likely had systemic follicular lymphoma involvement (Ann Arbor system staging IIIES/IV or Lugano system staging II-2/IV), involvement of 5 or more nodal areas, and presentation of bulky tumors in the gastrointestinal tract. These patients also presented a high Follicular Lymphoma International Prognostic Index (FLIPI) score, suggestive of poor prognosis. No differences were found among other clinical characteristics including sex, age at lymphoma diagnosis, histological grade, LDH levels, bone marrow involvement, hemoglobin levels, and identification of tracer accumulation in gastrointestinal lesions by positron-emission tomography scanning. Conclusions: sIL-2R levels can be used as an independent prognostic index in follicular lymphoma patients based on the correlation with the FLIPI score. Moreover, since high sIL-2R levels were associated with a large tumor bulk, sIL-2R may serve as a good indicator for monitoring disease relapse or progression.
AB - Objectives: Establish a correlation between serum soluble interleukin 2 receptor (sIL-2R) levels and clinical characteristics of follicular lymphoma patients with gastrointestinal involvement. Design and methods: Patients (n = 44) presenting with follicular lymphoma lesions in the gastrointestinal tract were enrolled into the study and divided into 2 groups based on sIL-2R levels (normal vs. elevated). Clinical characteristics were also analyzed between groups. Results: Patients with elevated sIL-2R levels likely had systemic follicular lymphoma involvement (Ann Arbor system staging IIIES/IV or Lugano system staging II-2/IV), involvement of 5 or more nodal areas, and presentation of bulky tumors in the gastrointestinal tract. These patients also presented a high Follicular Lymphoma International Prognostic Index (FLIPI) score, suggestive of poor prognosis. No differences were found among other clinical characteristics including sex, age at lymphoma diagnosis, histological grade, LDH levels, bone marrow involvement, hemoglobin levels, and identification of tracer accumulation in gastrointestinal lesions by positron-emission tomography scanning. Conclusions: sIL-2R levels can be used as an independent prognostic index in follicular lymphoma patients based on the correlation with the FLIPI score. Moreover, since high sIL-2R levels were associated with a large tumor bulk, sIL-2R may serve as a good indicator for monitoring disease relapse or progression.
KW - Gastrointestinal lymphoma
KW - Primary intestinal follicular lymphoma
KW - Soluble interleukin 2 receptor
UR - http://www.scopus.com/inward/record.url?scp=84893784739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893784739&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2013.11.026
DO - 10.1016/j.clinbiochem.2013.11.026
M3 - Article
C2 - 24362271
AN - SCOPUS:84893784739
VL - 47
SP - 191
EP - 195
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 3
ER -