Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement

Masaya Iwamuro, Katsuji Shinagawa, Hiroyuki Okada, Katsuyoshi Takata, Tadashi Yoshino, Kazuhide Yamamoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: Establish a correlation between serum soluble interleukin 2 receptor (sIL-2R) levels and clinical characteristics of follicular lymphoma patients with gastrointestinal involvement. Design and methods: Patients (n = 44) presenting with follicular lymphoma lesions in the gastrointestinal tract were enrolled into the study and divided into 2 groups based on sIL-2R levels (normal vs. elevated). Clinical characteristics were also analyzed between groups. Results: Patients with elevated sIL-2R levels likely had systemic follicular lymphoma involvement (Ann Arbor system staging IIIES/IV or Lugano system staging II-2/IV), involvement of 5 or more nodal areas, and presentation of bulky tumors in the gastrointestinal tract. These patients also presented a high Follicular Lymphoma International Prognostic Index (FLIPI) score, suggestive of poor prognosis. No differences were found among other clinical characteristics including sex, age at lymphoma diagnosis, histological grade, LDH levels, bone marrow involvement, hemoglobin levels, and identification of tracer accumulation in gastrointestinal lesions by positron-emission tomography scanning. Conclusions: sIL-2R levels can be used as an independent prognostic index in follicular lymphoma patients based on the correlation with the FLIPI score. Moreover, since high sIL-2R levels were associated with a large tumor bulk, sIL-2R may serve as a good indicator for monitoring disease relapse or progression.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalClinical Biochemistry
Volume47
Issue number3
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Follicular Lymphoma
Interleukin-2 Receptors
Tumors
Neoplasms
Gastrointestinal Tract
Positron emission tomography
Sex Characteristics
Positron-Emission Tomography
Lymphoma
Bone
Hemoglobins
Bone Marrow
Scanning
Recurrence
Monitoring
Serum

Keywords

  • Gastrointestinal lymphoma
  • Primary intestinal follicular lymphoma
  • Soluble interleukin 2 receptor

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement. / Iwamuro, Masaya; Shinagawa, Katsuji; Okada, Hiroyuki; Takata, Katsuyoshi; Yoshino, Tadashi; Yamamoto, Kazuhide.

In: Clinical Biochemistry, Vol. 47, No. 3, 02.2014, p. 191-195.

Research output: Contribution to journalArticle

@article{8eb5c4000b534cc494a62af6dcaf8495,
title = "Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement",
abstract = "Objectives: Establish a correlation between serum soluble interleukin 2 receptor (sIL-2R) levels and clinical characteristics of follicular lymphoma patients with gastrointestinal involvement. Design and methods: Patients (n = 44) presenting with follicular lymphoma lesions in the gastrointestinal tract were enrolled into the study and divided into 2 groups based on sIL-2R levels (normal vs. elevated). Clinical characteristics were also analyzed between groups. Results: Patients with elevated sIL-2R levels likely had systemic follicular lymphoma involvement (Ann Arbor system staging IIIES/IV or Lugano system staging II-2/IV), involvement of 5 or more nodal areas, and presentation of bulky tumors in the gastrointestinal tract. These patients also presented a high Follicular Lymphoma International Prognostic Index (FLIPI) score, suggestive of poor prognosis. No differences were found among other clinical characteristics including sex, age at lymphoma diagnosis, histological grade, LDH levels, bone marrow involvement, hemoglobin levels, and identification of tracer accumulation in gastrointestinal lesions by positron-emission tomography scanning. Conclusions: sIL-2R levels can be used as an independent prognostic index in follicular lymphoma patients based on the correlation with the FLIPI score. Moreover, since high sIL-2R levels were associated with a large tumor bulk, sIL-2R may serve as a good indicator for monitoring disease relapse or progression.",
keywords = "Gastrointestinal lymphoma, Primary intestinal follicular lymphoma, Soluble interleukin 2 receptor",
author = "Masaya Iwamuro and Katsuji Shinagawa and Hiroyuki Okada and Katsuyoshi Takata and Tadashi Yoshino and Kazuhide Yamamoto",
year = "2014",
month = "2",
doi = "10.1016/j.clinbiochem.2013.11.026",
language = "English",
volume = "47",
pages = "191--195",
journal = "Clinical Biochemistry",
issn = "0009-9120",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement

AU - Iwamuro, Masaya

AU - Shinagawa, Katsuji

AU - Okada, Hiroyuki

AU - Takata, Katsuyoshi

AU - Yoshino, Tadashi

AU - Yamamoto, Kazuhide

PY - 2014/2

Y1 - 2014/2

N2 - Objectives: Establish a correlation between serum soluble interleukin 2 receptor (sIL-2R) levels and clinical characteristics of follicular lymphoma patients with gastrointestinal involvement. Design and methods: Patients (n = 44) presenting with follicular lymphoma lesions in the gastrointestinal tract were enrolled into the study and divided into 2 groups based on sIL-2R levels (normal vs. elevated). Clinical characteristics were also analyzed between groups. Results: Patients with elevated sIL-2R levels likely had systemic follicular lymphoma involvement (Ann Arbor system staging IIIES/IV or Lugano system staging II-2/IV), involvement of 5 or more nodal areas, and presentation of bulky tumors in the gastrointestinal tract. These patients also presented a high Follicular Lymphoma International Prognostic Index (FLIPI) score, suggestive of poor prognosis. No differences were found among other clinical characteristics including sex, age at lymphoma diagnosis, histological grade, LDH levels, bone marrow involvement, hemoglobin levels, and identification of tracer accumulation in gastrointestinal lesions by positron-emission tomography scanning. Conclusions: sIL-2R levels can be used as an independent prognostic index in follicular lymphoma patients based on the correlation with the FLIPI score. Moreover, since high sIL-2R levels were associated with a large tumor bulk, sIL-2R may serve as a good indicator for monitoring disease relapse or progression.

AB - Objectives: Establish a correlation between serum soluble interleukin 2 receptor (sIL-2R) levels and clinical characteristics of follicular lymphoma patients with gastrointestinal involvement. Design and methods: Patients (n = 44) presenting with follicular lymphoma lesions in the gastrointestinal tract were enrolled into the study and divided into 2 groups based on sIL-2R levels (normal vs. elevated). Clinical characteristics were also analyzed between groups. Results: Patients with elevated sIL-2R levels likely had systemic follicular lymphoma involvement (Ann Arbor system staging IIIES/IV or Lugano system staging II-2/IV), involvement of 5 or more nodal areas, and presentation of bulky tumors in the gastrointestinal tract. These patients also presented a high Follicular Lymphoma International Prognostic Index (FLIPI) score, suggestive of poor prognosis. No differences were found among other clinical characteristics including sex, age at lymphoma diagnosis, histological grade, LDH levels, bone marrow involvement, hemoglobin levels, and identification of tracer accumulation in gastrointestinal lesions by positron-emission tomography scanning. Conclusions: sIL-2R levels can be used as an independent prognostic index in follicular lymphoma patients based on the correlation with the FLIPI score. Moreover, since high sIL-2R levels were associated with a large tumor bulk, sIL-2R may serve as a good indicator for monitoring disease relapse or progression.

KW - Gastrointestinal lymphoma

KW - Primary intestinal follicular lymphoma

KW - Soluble interleukin 2 receptor

UR - http://www.scopus.com/inward/record.url?scp=84893784739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893784739&partnerID=8YFLogxK

U2 - 10.1016/j.clinbiochem.2013.11.026

DO - 10.1016/j.clinbiochem.2013.11.026

M3 - Article

C2 - 24362271

AN - SCOPUS:84893784739

VL - 47

SP - 191

EP - 195

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

IS - 3

ER -