Elevated serum interleukin-18 levels might reflect the high risk of hospitalization in patients on peritoneal dialysis

A. I. Yano, Kazushi Nakao, A. I. Sarai, Shigeru Akagi, Takashi Kihara, Hisanori Morimoto, Akihiko Nakamura, Makoto Hiramatsu, Yoshio Nagake, Hirofumi Makino

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Abstract

Background: Interleukin (IL)-18 is a potent pro-inflammatory cytokine and plays a central role in atherosclerotic plaque rupture and accelerates atherosclerosis. Aim: The aim of this study was to determine serum IL-18 levels in patients on peritoneal dialysis (PD) and to assess their relationship with hospitalization. Methods: Forty-three PD patients and 20 healthy individuals were enrolled in this study. We investigated the relationship of the serum concentrations of IL-18 and other well-established atherosclerotic markers, such as asymmetric dimethylarginine (ADMA). Hospitalization data from over a 18-month period were prospectively obtained on all 43 PD patients. Classic factors were entered into a Cox regression model to predict first hospitalization. Results: The serum levels of IL-18 in patients on PD were significantly higher than those of healthy individuals (228.5 ± 140.3 pg/mL vs 154.8 ± 44.7 pg/mL, P < 0.05, respectively). Furthermore, serum IL-18 levels showed a positive correlation with duration of PD, serum β2 microglobulin and serum ADMA levels. Mean serum levels of IL-18 were significantly higher among patients who had experienced at least one hospitalization than those who had not (279.9 ± 164.3 vs 158.5 ± 43.9 pg/mL, P = 0.0426). Furthermore, the relative risk for first hospitalization for each increase in IL-18 (pg/mL) levels was associated with a 1.182 (95% confidence interval, 1.012-1.364; P = 0.0071) increase in the risk for future hospitalization events. Conclusion: The present study suggests the elevated serum IL-18 levels might increase the risk for future hospitalization in patients on PD.

Original languageEnglish
Pages (from-to)576-582
Number of pages7
JournalNephrology
Volume10
Issue number6
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Asymmetric dimethylarginine
  • Hospitalization
  • Interleukin-18
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Nephrology

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    Yano, A. I., Nakao, K., Sarai, A. I., Akagi, S., Kihara, T., Morimoto, H., Nakamura, A., Hiramatsu, M., Nagake, Y., & Makino, H. (2005). Elevated serum interleukin-18 levels might reflect the high risk of hospitalization in patients on peritoneal dialysis. Nephrology, 10(6), 576-582. https://doi.org/10.1111/j.1440-1797.2005.00497.x