Elevated serum interferon Î 3-induced protein 10 kDa is associated with TAFRO syndrome

Noriko Iwaki, Yuka Gion, Eisei Kondo, Mitsuhiro Kawano, Taro Masunari, Hiroshi Moro, Koji Nikkuni, Kazue Takai, Masao Hagihara, Yuko Hashimoto, Kenji Yokota, Masataka Okamoto, Shinji Nakao, Tadashi Yoshino, Yasuharu Sato

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It is characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the disease pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although the etiology of HHV-8-negative MCD is idiopathic (iMCD). A distinct subtype of iMCD that shares a constellation of clinical features including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O) has been reported as TAFRO-iMCD, however the differences in cytokine profiles between TAFRO-iMCD and iMCD have not been established. We retrospectively compared levels of serum interferon Î 3-induced protein 10 kDa (IP-10), platelet-derived growth factor (PDGF)-AA, interleukin (IL)-10, and other cytokines between 11 cases of TAFRO-iMCD, 6 cases of plasma cell type iMCD, and 21 healthy controls. During flare-ups, patients with TAFRO-iMCD had significantly higher serum IP-10 and tended to have lower PDGF-AA levels than the other 2 groups. In addition, serum IL-10, IL-23, and vascular endothelial growth factor-A were elevated in both TAFRO-iMCD and iMCD. Elevated serum IP-10 is associated with inflammatory diseases including infectious diseases. There was a strong correlation between high serum IP-10 and the presence of TAFRO-iMCD, suggesting that IP-10 might be involved in the pathogenesis of TAFRO-iMCD.

Original languageEnglish
Article number42316
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - Feb 13 2017

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Interferons
Human Herpesvirus 8
Serum
Platelet-Derived Growth Factor
Proteins
Interleukin-10
Cytokines
Reticulin
Interleukin-23
Lymphoproliferative Disorders
Plasma Cells
Thrombocytopenia
Vascular Endothelial Growth Factor A
Communicable Diseases
Interleukin-6
Edema
Fibrosis
Fever
Multi-centric Castleman's Disease

ASJC Scopus subject areas

  • General

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Elevated serum interferon Î 3-induced protein 10 kDa is associated with TAFRO syndrome. / Iwaki, Noriko; Gion, Yuka; Kondo, Eisei; Kawano, Mitsuhiro; Masunari, Taro; Moro, Hiroshi; Nikkuni, Koji; Takai, Kazue; Hagihara, Masao; Hashimoto, Yuko; Yokota, Kenji; Okamoto, Masataka; Nakao, Shinji; Yoshino, Tadashi; Sato, Yasuharu.

In: Scientific Reports, Vol. 7, 42316, 13.02.2017.

Research output: Contribution to journalArticle

Iwaki, N, Gion, Y, Kondo, E, Kawano, M, Masunari, T, Moro, H, Nikkuni, K, Takai, K, Hagihara, M, Hashimoto, Y, Yokota, K, Okamoto, M, Nakao, S, Yoshino, T & Sato, Y 2017, 'Elevated serum interferon Î 3-induced protein 10 kDa is associated with TAFRO syndrome', Scientific Reports, vol. 7, 42316. https://doi.org/10.1038/srep42316
Iwaki, Noriko ; Gion, Yuka ; Kondo, Eisei ; Kawano, Mitsuhiro ; Masunari, Taro ; Moro, Hiroshi ; Nikkuni, Koji ; Takai, Kazue ; Hagihara, Masao ; Hashimoto, Yuko ; Yokota, Kenji ; Okamoto, Masataka ; Nakao, Shinji ; Yoshino, Tadashi ; Sato, Yasuharu. / Elevated serum interferon Î 3-induced protein 10 kDa is associated with TAFRO syndrome. In: Scientific Reports. 2017 ; Vol. 7.
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AU - Moro, Hiroshi

AU - Nikkuni, Koji

AU - Takai, Kazue

AU - Hagihara, Masao

AU - Hashimoto, Yuko

AU - Yokota, Kenji

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AU - Nakao, Shinji

AU - Yoshino, Tadashi

AU - Sato, Yasuharu

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