Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease

Yukiko Ueda, Yuko Kawakami, Daisuke Kunii, Hiroyuki Okada, Masami Azuma, Duc Son N T Le, Shigeru Yamamoto

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and lipid metabolism. This study examined the qualitative and quantitative fat intake of IBD patients and healthy controls on plasma phospholipid and erythrocyte membrane phospholipid (EMP) fatty acid content. Measurement of the fatty acid composition of plasma phospholipid and EMP were performed in 29 UC patients, 20 CD patients, and 31 healthy controls. Anthropometric characteristics and data on dietary intake were also collected. We observed significantly lower lipid intake in UC and CD patients vs controls. The UC and CD patients had significantly higher levels of linoleic acid in their EMP than did controls. There were no significant differences in the levels of n-3 polyunsaturated fatty acids, but there were significantly higher levels of the n-6 in the EMP of UC and CD patients compared with controls. The significant differences persisted after the data were adjusted for potential confounders and lipid intake. Higher levels of linoleic acids and n-6 fatty acids, which are involved in production of proinflammatory mediators, were found in IBD patients compared with controls, thereby implicating n-6 fatty acids in the pathophysiology of the disease.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalNutrition Research
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Erythrocyte Membrane
Linoleic Acid
Inflammatory Bowel Diseases
Phospholipids
Ulcerative Colitis
Crohn Disease
Fatty Acids
Cell Membrane
Linoleic Acids
Inflammation
Lipids
Dietary Fats
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Lipid Metabolism
Gastrointestinal Tract
Fats

Keywords

  • Eicosanoids
  • Erythrocyte membrane phospholipids
  • Human
  • Inflammatory bowel disease
  • n-6 and n-3 fatty acids
  • Plasma phospholipids
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. / Ueda, Yukiko; Kawakami, Yuko; Kunii, Daisuke; Okada, Hiroyuki; Azuma, Masami; Le, Duc Son N T; Yamamoto, Shigeru.

In: Nutrition Research, Vol. 28, No. 4, 04.2008, p. 239-244.

Research output: Contribution to journalArticle

Ueda, Yukiko ; Kawakami, Yuko ; Kunii, Daisuke ; Okada, Hiroyuki ; Azuma, Masami ; Le, Duc Son N T ; Yamamoto, Shigeru. / Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. In: Nutrition Research. 2008 ; Vol. 28, No. 4. pp. 239-244.
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