Abstract
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and lipid metabolism. This study examined the qualitative and quantitative fat intake of IBD patients and healthy controls on plasma phospholipid and erythrocyte membrane phospholipid (EMP) fatty acid content. Measurement of the fatty acid composition of plasma phospholipid and EMP were performed in 29 UC patients, 20 CD patients, and 31 healthy controls. Anthropometric characteristics and data on dietary intake were also collected. We observed significantly lower lipid intake in UC and CD patients vs controls. The UC and CD patients had significantly higher levels of linoleic acid in their EMP than did controls. There were no significant differences in the levels of n-3 polyunsaturated fatty acids, but there were significantly higher levels of the n-6 in the EMP of UC and CD patients compared with controls. The significant differences persisted after the data were adjusted for potential confounders and lipid intake. Higher levels of linoleic acids and n-6 fatty acids, which are involved in production of proinflammatory mediators, were found in IBD patients compared with controls, thereby implicating n-6 fatty acids in the pathophysiology of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 239-244 |
| Number of pages | 6 |
| Journal | Nutrition Research |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2008 |
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Keywords
- Eicosanoids
- Erythrocyte membrane phospholipids
- Human
- Inflammatory bowel disease
- n-6 and n-3 fatty acids
- Plasma phospholipids
- Polyunsaturated fatty acids
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. / Ueda, Yukiko; Kawakami, Yuko; Kunii, Daisuke; Okada, Hiroyuki; Azuma, Masami; Le, Duc Son N T; Yamamoto, Shigeru.
In: Nutrition Research, Vol. 28, No. 4, 04.2008, p. 239-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease
AU - Ueda, Yukiko
AU - Kawakami, Yuko
AU - Kunii, Daisuke
AU - Okada, Hiroyuki
AU - Azuma, Masami
AU - Le, Duc Son N T
AU - Yamamoto, Shigeru
PY - 2008/4
Y1 - 2008/4
N2 - Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and lipid metabolism. This study examined the qualitative and quantitative fat intake of IBD patients and healthy controls on plasma phospholipid and erythrocyte membrane phospholipid (EMP) fatty acid content. Measurement of the fatty acid composition of plasma phospholipid and EMP were performed in 29 UC patients, 20 CD patients, and 31 healthy controls. Anthropometric characteristics and data on dietary intake were also collected. We observed significantly lower lipid intake in UC and CD patients vs controls. The UC and CD patients had significantly higher levels of linoleic acid in their EMP than did controls. There were no significant differences in the levels of n-3 polyunsaturated fatty acids, but there were significantly higher levels of the n-6 in the EMP of UC and CD patients compared with controls. The significant differences persisted after the data were adjusted for potential confounders and lipid intake. Higher levels of linoleic acids and n-6 fatty acids, which are involved in production of proinflammatory mediators, were found in IBD patients compared with controls, thereby implicating n-6 fatty acids in the pathophysiology of the disease.
AB - Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and lipid metabolism. This study examined the qualitative and quantitative fat intake of IBD patients and healthy controls on plasma phospholipid and erythrocyte membrane phospholipid (EMP) fatty acid content. Measurement of the fatty acid composition of plasma phospholipid and EMP were performed in 29 UC patients, 20 CD patients, and 31 healthy controls. Anthropometric characteristics and data on dietary intake were also collected. We observed significantly lower lipid intake in UC and CD patients vs controls. The UC and CD patients had significantly higher levels of linoleic acid in their EMP than did controls. There were no significant differences in the levels of n-3 polyunsaturated fatty acids, but there were significantly higher levels of the n-6 in the EMP of UC and CD patients compared with controls. The significant differences persisted after the data were adjusted for potential confounders and lipid intake. Higher levels of linoleic acids and n-6 fatty acids, which are involved in production of proinflammatory mediators, were found in IBD patients compared with controls, thereby implicating n-6 fatty acids in the pathophysiology of the disease.
KW - Eicosanoids
KW - Erythrocyte membrane phospholipids
KW - Human
KW - Inflammatory bowel disease
KW - n-6 and n-3 fatty acids
KW - Plasma phospholipids
KW - Polyunsaturated fatty acids
UR - http://www.scopus.com/inward/record.url?scp=41549164721&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41549164721&partnerID=8YFLogxK
U2 - 10.1016/j.nutres.2008.02.005
DO - 10.1016/j.nutres.2008.02.005
M3 - Article
C2 - 19083414
AN - SCOPUS:41549164721
VL - 28
SP - 239
EP - 244
JO - Nutrition Research
JF - Nutrition Research
SN - 0271-5317
IS - 4
ER -